Accounting Manager

xairatherapeutics

South San Francisco, California, United States · South San Francisco · United States

Posted Apr 24, 2026

Other
Finance

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Job description

About Xaira Therapeutics

Xaira is an innovative biotech startup focused on leveraging AI to transform drug discovery and development. The company is leading the development of generative AI models to design protein and antibody therapeutics, enabling the creation of medicines against historically hard-to-drug molecular targets. It is also developing foundation models for biology and disease to enable better target elucidation and patient stratification. Collectively, these technologies aim to continually enable the identification of novel therapies and to improve success in drug development. Xaira is headquartered in the San Francisco Bay Area, Seattle, and London.

About the Role

As the Accounting Manager, reporting directly to the Corporate Controller, you will manage and administer all accounting operations and other ad hoc analysis as required. You will help manage a team of contractors supporting day to day functions while laying the groundwork for an in-house team that you will build and grow over time. This is a hands-on, high-impact role where you will have the unique opportunity to create scalable systems, establish best practices, and drive the development of a robust accounting infrastructure that positions Xaira for long-term success.

Key Responsibilities

Participate in the month-end, quarter-end and year-end financial close process, preparing journal entries, balance sheet and income statement account reconciliations and analyses for various accounts timely, including but not limited to prepaids, accruals, leases (ASC 842), fixed assets and account reconciliations.
Prepare the monthly management financial packages (with analysis) and other management reports as requested (this includes understanding and clearly articulating the financial results of the company and preparing balance sheet, income statement fluctuation)
Reconcile payroll-related accounts and prepare payroll journal entries.
Collaborate and coordinate with various business partners to obtain required financial reporting information and develop improvements to the financial reporting process.
Assist account payable operations, including vendor invoices, payment processing, and purchase order reconciliation.
Identify opportunities to automate and improve accounting processes using ERP systems or other tools.
Ensure compliance with regulatory requirements, including tax filings, audit readiness, and financial reporting standards.
Work with cross-functional teams across the company to ensure proper support for the business unit.
Able to deliver results in a fast-paced work environment.

Qualifications

5+ years of progressive accounting/finance experience, ideally a public accounting and private industry mix
Biotech/pharmaceutical industry experience preferred
Strong project management skills with the ability to manage competing priorities and meet tight deadlines
Demonstrated ability to manage external service providers and cross functional relationships.
Self-starter with a collaborative mindset and a passion for working in a mission-driven organization
Proficiency in NetSuite and advanced Excel and Google Suite of products (Sheets, Docs) is a plus
Ability to prioritize assignments, deal with interruptions, and meet deadlines in a fast paced and growth oriented environment

Compensation

We offer a competitive compensation and benefits package, seeking to provide an open, flexible, and friendly work environment to empower employees and provide them with a platform to develop their long-term careers. A Summary of Benefits is available for all applicants. The base pay range for this position is expected to be $135,000 - $155,000 annually; however, the base pay offered may vary depending on the market, job-related knowledge, skills and capabilities, and experience.

Xaira Therapeutics an equal-opportunity employer. We believe that our strength is in our differences. Our goal to build a diverse and inclusive team began on day one, and it will never end.

TO ALL RECRUITMENT AGENCIES: Xaira Therapeutics does not accept agency resumes. Please do not forward resumes to our jobs alias or employees. XairaTherapeutics is not responsible for any fees related to unsolicited resumes.