Associate Director, Clinical Portfolio Technology

Overview Alnylam is seeking a highly collaborative Associate Director, Clinical Portfolio Technology, to help shape, deliver, and continuously improve technology capabilities that support Clinical Delivery, Portfolio Management, and related Development functions. Reporting to the Senior Director, Clinical Portfolio Technology, this individual will partner closely with Clinical Portfolio Services, Global Trial Optimization, Study Management, Data Science, Statistics and Epidemiology DSSE), , and IT to translate business priorities into compliant, scalable, and user-focused solutions. The ideal candidate brings strong knowledge of clinical trial technology, the ability to connect Clinical Development and IT in a practical and credible way, and a growth mindset with interest in emerging capabilities, including AI, and how they can be applied responsibly in a regulated environment. Responsibilities In this role, you will help drive the successful delivery, adoption, and continuous improvement of technology capabilities that support clinical trial execution, study oversight, and portfolio decision-making across Development. Partner with the Senior Director and stakeholders across Clinical Operations, Study Management, Portfolio Management, and DSSE to translate business priorities into technology plans, aligned roadmaps, and measurable outcomes. Support the delivery, enhancement, and lifecycle management of platforms and capabilities that enable trial execution, study oversight, portfolio analytics, and data-driven decision-making across Development. Serve as a key liaison between Clinical Development and IT, ensuring business needs, technical considerations, risks, priorities, and trade-offs are clearly understood and effectively translated across teams. Coordinate with product owners, vendors, and internal IT teams to manage requirements, scope, dependencies, testing, issue resolution, and release readiness across clinical technology initiatives. Help ensure solutions are compliant, validated, and inspection-ready, consistent with GxP expectations, including 21 CFR Part 11, EU Annex 11, change control, documentation, and quality practices. Drive operational excellence and continuous improvement by identifying opportunities to simplify processes, improve data flows, reduce manual effort, and enhance the user experience across clinical systems. Apply broad knowledge of clinical trial technology, including the systems, integrations, data, and operational processes that support modern clinical delivery in a regulated environment. Collaborate with Quality, Security, Architecture, Infrastructure, Integration, Analytics, and application teams to ensure solutions are secure, scalable, supportable, and aligned with enterprise standards. Demonstrate strong learning agility and curiosity, with the ability to build knowledge in new domains and emerging capabilities, including AI, and apply them responsibly in support of Clinical Development. Contribute to a team culture defined by transparency, responsiveness, shared ownership, curiosity, and strong cross-functional partnership. Qualifications The successful candidate will bring a combination of relevant experience, sound judgment, learning agility, and the ability to operate effectively across Clinical Development and IT in a regulated environment. Required Bachelor’s degree in Information Technology, Computer Science, Life Sciences, or a related field ; advanced degree preferred. 8+ years of experience in life sciences technology, including significant experience supporting clinical development platforms in regulated environments. Strong understanding of clinical trial processes, systems, and operating models, with the ability to translate operational needs into effective technology solutions. Working knowledge of GxP expectations, including 21 CFR Part 11, EU Annex 11, validation, change control, and inspection readiness principles. Experience working with major life sciences technology vendors and cross-functional delivery teams in support of regulated business processes. Strong communication and stakeholder management skills, including the ability to engage effectively with both business stakeholders and technical teams. Demonstrated collaboration, sound judgment, learning agility, and a hands-on approach to delivery and problem-solving. Preferred Experience with platforms and capabilities such as Medidata, SAS, R/Posit, Veeva Vault, Elluminate, CTMS, EDC, eCOA, eTMF, RBQM, oversight & clinical dashboards, and portfolio management tools. Familiarity with data standards, integrations, analytics, or visualization capabilities that support clinical development decision-making. Interest in AI-enabled capabilities and the ability to evaluate how they may be applied responsibly to support clinical development. Familiarity with Agile delivery practices, product-oriented ways of working, and structured vendor management. #LI-LN1 #LI-HYBRID U.S. Pay Range $172,200.00 - $233,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.