Associate Scientist II, Biology

**Overview** We are seeking a talented candidate to fill an Associate Scientist II position within Alnylam’s Research department. This position is an opportunity to potentially see one’s work progress from the bench to the clinic and positively impact patients’ lives. The successful candidate will support development of current therapeutic programs as part of a multidisciplinary team and be involved in the discovery of RNAi compounds for a variety of novel indications and support their entry into the clinic. The successful candidate will have background in biological sciences and be technically skilled in basic laboratory techniques. Responsibilities will include designing, developing, and executing studies in rodent disease models, evaluation of small interfering RNAs (siRNAs) in wild-type animals, and conducting the associated *in vitro* molecular-based assays such as transcript and protein quantitation. Collaborative curiosity, passion for science, and a desire to learn new techniques are a must. **Responsibilities** - Contribute to study design and execution of studies to characterize compounds for RNAi therapeutic programs, including rodent disease models (or other preclinical models) - Develop and conduct assays such as qPCR, western blot, and ELISA, that support *in vivo* and *in vitro* studies - Perform *in vitro* and cell-based assays to characterize drug activity or mechanism of action - Perform *in vivo* procedures in rodents, including administration of therapeutics via established methodologies - Analyze and interpret the data - Prepare clearly articulated experimental reports and data presentations - Prepare and develop protocols and methodologies - Present data to groups within and outside of Research **Qualifications** - Bachelors degree in a life sciences-related discipline such as Molecular Biology, Cell Biology, Genetics with 1-3 years relevant experience or a Masters degree with 1 year of relevant experience - Proficiency in RNA/DNA/protein analysis techniques, including RNA isolation, ELISA, western blotting and RT-qPCR - Cell/tissue culture experience - Basic rodent *in vivo* skills is a plus - Experience setting up rodent disease models is a plus - Ability to perform and troubleshoot assays independently or with limited direction of supervisor(s)/project leader(s) - Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reports - Must be flexible, open to new tasks and challenges, and able to work on tight deadlines - Proven ability to work in a team environment and across functional areas - Cover letter encouraged #LI-JR1 **U.S. Pay Range** **$67,600.00 - $101,400.00** The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. *Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: * **About Alnylam** We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.