Bio-Analytical Co-op-Northeastern Students

Seaport Therapeutics is a clinical-stage therapeutics company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary GlyphTM technology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinicians and key opinion leaders. For more information, please visit [](https://www.seaporttx.com/). **Job Description** Seaport Therapeutics is seeking a co-op student for a lab-based bioanalysis position to be part of our Discovery team. This co-op will have a focus on LC-MS to assist in the screening of novel drugs. We are looking for a highly motivated individual who is looking to be a part of a multidisciplinary team and to gain experience in a startup environment. This position will contribute to advancing the pipeline of impactful candidates generated from our novel Glyph™ prodrug platform. Some of the responsibilities will include: - Executing *in vitro* experiments, using LC-MS, for the screening of lipid prodrugs to support preclinical discovery - Processing and analyzing *in vivo* samples (plasma, lymph fluid, etc.) to generate DMPK data for various prodrugs - Contributing to the development and optimization of LC-MS methods for both quantitative and qualitative analysis - Routine use and troubleshooting of LC-MS instrumentation - Documenting all experiments using an electronic notebook and analyzing data for reports and regular internal presentations **Experience and Skills** - Enrolled in a Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, or related program at the Master’s Level - Previous Co-op or lab experience is preferred - Knowledge of or experience with: HPLC, reverse phase chromatography, mass spectrometry instrumentation, enzyme kinetics, protein precipitation, liquid-liquid extraction - Strong organizational skills, attention to detail, and eagerness to learn.