Business Engagement & Technology Principal Analyst

Job Description Job Title Principal Business Analyst, Cell & Gene Therapy Commercial Technology Company Overview Vertex Pharmaceuticals is a global biotechnology company committed to investing in scientific innovation to create transformative medicines for people with serious diseases. Our teams combine science, technology, and operational excellence to advance therapies that can change patients’ lives. At Vertex, we foster a collaborative, inclusive environment where employees are empowered to solve complex challenges and drive meaningful impact across the enterprise. Role Summary Vertex is seeking a Principal Business Analyst, Cell & Gene Therapy Commercial Technology to join the Data, Technology and Engineering (DTE) team and play a key role in shaping and supporting technology solutions for our Cell & Gene Therapy commercial organization. This individual will partner closely with commercial stakeholders and technology teams to define business needs, improve processes, and enable scalable digital capabilities that support scaling operations , order management , analytics, and end to end patient journey across multiple platforms and technologies. The ideal candidate will bring strong business analysis expertise , deep stakeholder management skills, experience delivering AI and automation and supporting commercial functions within biotechnology, pharmaceuticals, or other regulated industries. This role requires a blend of strategic thinking, process optimization, and hands-on delivery support to ensure technology solutions align with business priorities and compliance expectations. Work Model: Hybrid or on-site Key Responsibilities • Partner with Commercial, Cell & Gene Therapy, and Technology stakeholders to understand business strategies, priorities, and operational challenges • Lead requirements gathering, business process analysis, and solution design for complex commercial technology initiatives • Translate business needs into detailed functional requirements, user stories, process maps, business rules, and solution recommendations • Support technology initiatives across key commercial domains such as patient services, order management, field enablement, commercial analytics, and data integration - Partner with business and technical teams to help define and deliver AI and automation use cases aligned to business priorities • Analyze current-state and future-state business processes to identify opportunities for standardization, automation, and optimization • Facilitate cross-functional workshops and working sessions to align stakeholders on priorities, requirements, and solution outcomes • Collaborate with product managers, architects, developers, data teams, and vendors to ensure solutions meet business objectives and enterprise standards • Drive business readiness activities including testing support, user acceptance testing, training coordination, adoption planning, and change management • Ensure solutions align with relevant compliance, privacy, legal, promotional review, and regulated industry requirements • Develop and maintain high-quality documentation including business requirements, process flows, use cases, impact assessments, and traceability artifacts • Use data, metrics, and stakeholder feedback to evaluate solution effectiveness and support continuous improvement • C ontribute to business analysis best practices across the commercial technology organization Required Qualifications • Bachelor’s degree in Business , Information Systems, Life Sciences, Engineering, or a related field • Significant experience in business analysis, product delivery, process improvement, or related roles within biotechnology, pharmaceuticals, healthcare, or another regulated industry • Experience supporting commercial business functions and technology platforms, preferably in life sciences • Demonstrated ability to lead complex, cross-functional initiatives involving multiple business and technical stakeholders • Strong experience eliciting, documenting, validating , and managing business and functional requirements • Proven ability to analyze and improve business processes and translate them into technology-enabled solutions - Experience supporting or contributing to automation, advanced analytics, AI-enabled, or digital transformation initiatives • Experience working across the system or product delivery lifecycle, including planning, requirements, testing, implementation, and post-go-live support • Excellent communication, facilitation, presentation, and stakeholder management skills • Strong analytical, problem-solving, and organizational abilities • Understanding of compliance and documentation expectations in regulated business environments Technical Skills Required • Business and functional requirements documentation • Process mapping and business workflow analysis • User story creation and backlog refinement • Gap analysis and solution assessment • Data analysis, reporting, and dashboard requirements support • Stakeholder workshop facilitation • User acceptance testing support and test scenario development • Change management and training support • Familiarity with CRM and commercial technology ecosystems - Understanding of AI-enabled business solutions, workflow automation, and process digitization concepts • Knowledge of Agile, Waterfall, or hybrid project delivery methodologies • Proficiency with tools such as Jira, Confluence, Visio, Microsoft Excel, PowerPoint, Word, and other collaboration platforms • Understanding of enterprise data flows, integrations, and commercial reporting environments Preferred Skills • Experience supporting Cell & Gene Therapy commercial business models and technology capabilities , including Salesforce and AI • Knowledge of pharmaceutical or biotech commercial operations, including field engagement, market access, patient support, and launch planning • Experience with platforms such as CRM systems, data visualization tools, customer engagement platforms, and commercial analytics solutions - Experience with AI use case definition, intelligent automation, workflow tools, or emerging digital technologies in support of business operations • Familiarity with patient services, specialty distribution, HUB operations, and reimbursement-related workflows • Experience with digital transformation, automation, and master data or system integration initiatives • Understanding of privacy, promotional, legal, and compliance considerations in commercial technology • Relevant certifications such as CBAP, PMI-PBA, Agile, Scrum, or Lean Six Sigma • Advanced degree in Business, Information Systems, Life Sciences, or a related discipline #LI-hybrid #LI-JS1 At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients. Pay Range: $164,400 - $246,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid : work remotely up to two days per week; or select 2. On-Site : work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at