CAR T-Cell Engineering Scientist

Job description

• The scientist will be involved in establishing methodologies, i.e. culturing and activating primary T-cells, enriching T-cell populations, viral transductions and electroporation of primary cells, to generate CAR T-cells. • They will also be responsible for CAR T-cells based on current state of the art and novel constructs in vitro and in vivo to identify optimal constructs and characteristics for therapeutic uses • BS and 5+ years of experience or MS and 3+ years of experience in an academic and/or industrial setting. • Knowledge and hands-on experience in generating and optimizing human CAR T-cells is required. • Knowledge and experience of modern laboratory methodology in cellular and molecular T-cell immunology. • Knowledge and experience with viral based systems (lenti-virus, adenovirus, or murine retrovirus) to optimize transduction of cell-lines and primary cells. • Knowledge and experience in genome engineering (zinc fingers, TALEN, or CRISPR) is preferred. • Excellent written, oral communication skills. • 4-7 years of experience in Biochemical techniques. • 4-7 years of experience in Cell/Tissue Culture techniques. Integrated resources is a staffing company