Commercial Execution Architect

praxisprecisionmedicines

United States - Remote · Remote · United States

Posted Jun 12, 2026

Other
Remote
Sales

Job description

Location: This is a remote-based role that requires flexibility and willingness to travel within a specified region and for company-related purposes as needed.

The Opportunity

Praxis Precision Medicines is entering a pivotal moment as we prepare for commercialization, and how we build and scale capability across the organization will directly impact our success.

We are seeking a high-impact Commercial Execution Architect to design, implement, and continuously optimize the capabilities that drive field performance. This role will be responsible for ensuring the field organization is equipped with the right targets, incentives, data, and insights to execute effectively. Working closely with Commercial Leadership, Sales, Market Access, Medical Affairs, and external partners, you will play a critical role in enabling successful product launches and building a scalable, high-performing commercial infrastructure.

What You’ll Do

Lead the development and management of field force KPIs, dashboards, and performance tracking to drive accountability and results.
Design, implement, and administer incentive compensation plans, including goal setting, payout calculations, and governance.
Own quarterly targeting and segmentation processes to ensure optimal deployment of field resources.
Partner with Commercial Leadership to translate strategy into measurable field execution frameworks.
Manage relationships with external data vendors, ensuring data quality, integrity, and value.
Deliver actionable insights and analytics to inform decision-making and improve field effectiveness.
Support field readiness across pre-launch, launch, and post-launch phases through data, tools, and performance frameworks.
Collaborate cross-functionally with Finance, IT, Compliance, and Commercial Operations to ensure aligned and compliant execution.
Continuously evaluate and implement best practices, tools, and processes to enhance field force effectiveness and scalability.

How You Work

You think in systems, not silos.
You balance rigor with speed, knowing when each matters most.
You hold a high bar for performance, quality, and accountability.
You collaborate deeply but act with ownership and urgency.
You are passionate about building scalable, data-driven commercial capabilities.

What You Bring

5+ years of experience in pharmaceutical/biotech commercial operations, sales operations, or field force effectiveness.
Deep expertise in incentive compensation design and administration.
Strong experience with targeting, segmentation, and field analytics.
Experience managing pharmaceutical data vendors and syndicated data sources.
Demonstrated ability to translate data into actionable business insights.
Experience supporting product launches, ideally within CNS, rare disease, or specialty markets.
Ability to operate effectively in agile, fast-moving biotech environments.
Strong analytical, problem-solving, and communication skills.

Compensation & Benefits

At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together!

To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below. This range reflects the base salary the Company reasonably expects to pay for the position at the time of posting. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles.

Annualized Base Salary

$240,000—$265,000 USD

Company Overview

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.

Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE^® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.

Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com.

Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.