Director of In Vivo Pharmacology

Job description

**About Integrated Biosciences** At Integrated, we arefocused onadvancing small molecule therapeutics for age-related diseases. We have built a first-of-its-kind discovery platform at the intersection of phenotypic models of aging, chemistry, and AI. Backed by top-tier VCs, and with recent publications in *Cell* (2025), *Nature* (2024), *Nature Aging* (2023), and *Nature Protocols* (2025), we’re rapidly expanding our senior scientific team to accelerate our growing pipeline. **About the Role** We’re seeking a driven and experienced and scientifically rigorous Director of In Vivo Pharmacology to join us at a pivotal moment. In this leadership role, you’ll lead a team to conduct animal studies that drive our drug discovery pipeline forward. You will serve as the in-house expert on animal models, in vivo study design, and translational pharmacology. You’ll play a key role in shaping our scientific strategy and driving milestone achievements across our pipeline. If you’re someone who combines deep R&D rigor with a mindset that challenges convention, and you’re passionate about advancing breakthrough therapeutics, we want to hear from you. **You will** - Design, execute, and interpret in vivo pharmacology studies to support lead optimization, candidate selection, and IND-enabling activities across multiple small molecule programs. - Develop, validate, and implement disease-relevant animal models (efficacy, mechanistic, and tolerability) in collaboration with internal and external teams. - Define translational pharmacology strategies, including PK/PD modeling, biomarker selection, and dose prediction frameworks to support clinical translation. - Partner with DMPK, medicinal chemistry, and biology teams to integrate in vitro and in vivo data into holistic SAR and candidate progression decisions. - Oversee vivarium staffing, scheduling, and day-to-day operations in collaboration with animal care personnel; serve as primary scientific liaison to the IACUC committee. - Communicate study results clearly to internal stakeholders through high-quality data packages, presentations, and written reports. - Contribute to IND filings, regulatory submissions, and due diligence activities as needed. - Build and mentor a growing in vivo pharmacology team; contribute to a culture of scientific excellence and collaboration. **You’re a good fit if you have (required)** - PhD in pharmacology, physiology, cancer biology, or a related field, with 8+ years of relevant industry experience. - Deep expertise in small molecule in vivo pharmacology, including broad hands-on proficiency with rodent models of disease (oncology, metabolic, inflammation, or other therapeutic areas). - Strong understanding of PK/PD principles and experience integrating pharmacokinetic and pharmacodynamic data to guide compound optimization. - Comfort operating at both strategic and bench levels. - Demonstrated ability to lead, mentor, and build effective scientific teams. **Bonus Points For** - Experience in cardiometabolic disease and/or aging biology - Experience in toxicology - Comfort with cutting-edge data analysis, large data sets, pand pioneering AI approaches - Startup-ready mindset: agile, proactive, and comfortable with ambiguity in a fast-paced environment **Location & Logistics** - Visa sponsorship available where applicable. We’ll work with you to make it happen. - This role will be located at Redwood LIFE in Redwood City, CA, a modern and stunning life sciences complex in the Bay Area. - Start date: immediate. - We are an equal-opportunity employer and strongly encourage applications from individuals of diverse backgrounds, experiences, and perspectives. **Compensation & benefits** We offer a highly competitive salary, substantial equity, and comprehensive benefits, including medical and dental coverage, company-provided lunch, 401k match, and others.