Director, Translational Biology

virbiotechnologyinc

San Francisco, California, United States · San Francisco · United States

Posted May 21, 2026

Full-time
On-site
Research

Job description

Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes programs for chronic hepatitis delta and multiple PRO-XTEN^® dual-masked T-cell engagers across validated targets in solid tumor indications. Vir Biotechnology also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies.

Vir Biotechnology has exclusive rights to the universal PRO-XTEN^® masking platform for oncology and infectious disease. PRO-XTEN^® is a trademark of Amunix Pharmaceuticals, Inc., a Sanofi company.

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company where everyone feels supported and encouraged to give their best.

THE OPPORTUNITY

Vir Bio is looking for a Director, Translational Biology to drive biomarker strategy across our pipeline, from preclinical discovery through clinical development. Reporting to the VP, Translational Biology, you will translate complex immunologic and molecular insights into actionable plans that inform mechanism of action, dose selection, patient selection, and clinical outcomes in immune-oncology and related disease areas.

You will lead biomarker design and execution for key programs, oversee advanced translational assays in both preclinical models and human samples, and partner closely with discovery, clinical, data science, and external collaborators to deliver high-quality biomarker data. You will manage scientists, contribute to regulatory filings, and help build the infrastructure and partnerships needed to advance cutting-edge biomarker science.

This role is located in our San Francisco headquarters with an expectation of at least 3 days per week in office.

WHAT YOU'LL DO

Serve as the biomarker lead for specific programs from preclinical through clinical development
Develop and execute biomarker strategies, including design and oversight of preclinical biomarker assessments and contribution to clinical biomarker plans to inform dose selection and development of immune-oncology agents
Plan and oversee the validation and execution of human immunologic and molecular methods in preclinical and clinical studies to meet biomarker objectives
Support activities related to deliverables and documentation for regulatory submissions (e.g., INDs, BLAs/NDAs) and contribute to authoring INDs, IBs, clinical study protocols, and related documents
Manage pilots and method validation with external vendors to ensure robust, fit-for-purpose biomarker assays
Collaborate with discovery, clinical, and data science colleagues to refine biomarker hypotheses, design studies, and analyze and interpret key datasets
Lead a team, providing scientific guidance and mentorship in immunology and biomarkers while overseeing team performance and development
Represent the Research function in selected external meetings, providing scientific input to support partnerships, due diligence, and program evaluations
Help develop and manage internal and external resources, including CROs and academic collaborators, to advance biomarker discovery and implementation

WHO YOU ARE AND WHAT YOU BRING

PhD and 10+ years, or MS and 13+ years, of relevant industry-focused experience in immune-oncology, immunology, or a closely related field, including drug and biomarker development from preclinical through Ph1–3 clinical stages
Proven track record in designing and executing biomarker strategies, encompassing biomarker identification, validation, and characterization in vitro and in vivo to inform mechanism of action, dose selection, and patient stratification
Deep subject-matter expertise in immunology and immune-oncology
Proficiency with immunology assays (e.g., polychromatic flow cytometry, cytotoxicity, T cell function, antigen presentation, and other in vitro systems)
Demonstrated ability to develop and implement robust, qualified/validated biomarker methods for clinical use, including oversight of assay pilots and method validation with external vendors/CROs
Strong background in contributing to regulatory documents in support of translational and clinical programs
Familiarity with the development or application of diagnostic or companion diagnostic tests for patient enrichment, selection, or prediction of therapeutic efficacy
Demonstrated scientific and people leadership, including managing scientists and leading cross-functional translational or biomarker teams

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WHO WE ARE AND WHAT WE OFFER

The expected salary range for this position is $207,500 to $261,500 per year. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.

Vir Biotechnology's compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes compensation, bonus and equity as well as many other Vir Biotechnology benefits and perks such as health and welfare benefit plans, non-accrual paid time off, company shut down for holidays, commuter benefits, 401K match and lunch each day in the office.

Applicants must currently be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

All employment decisions at Vir Biotechnology are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to any legally protected characteristics.

This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs. Vir Biotechnology also strongly commits to providing employees with a work environment free of unlawful conduct or harassment.

Vir Biotechnology Human Resources leads recruitment and employment for Vir Biotechnology. Unsolicited resumes sent to the company from recruiters do not constitute any type of relationship between the recruiter and Vir Biotechnology and do not obligate us to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

For hires based in the United States, Vir Biotechnology, participates in E-Verify.

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