gRNA Process Development Scientist

Job description

We are seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will be contributing to gRNA drug substance process development for programs in clinical development. In this role, the candidate will synthesize, purify, and characterize gRNAs in an effort to develop drug substance manufacturing processes and controls. Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing. Execute routine analytics including HPLC and UV-Vis. Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs. Compile and present data to team members and key stakeholders Maintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed. Uphold lab safety to the highest level of standards. Minimum Required Qualifications: B.S./M.S. degree in chemistry, chemical engineering, or biochemistry (or related field) with at least 2 years of relevant laboratory industry experience Experience with oligonucleotide synthesis and purification equipment (experience with gRNA or longmer synthesis and purification development is a plus) Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop. Experience with Tangital Flow Filtration (TFF) is required. Ability to follow established SOPs for routine analytical support. Experience with good documentation practices and electronic lab notebooks such as Benchling. Unwavering commitment to safety protocols and procedures. Strong attention to detail, organizational, and time-management skills. Effective communication skills for collaborating with team members and conveying technical information clearly. Strong problem-solving abilities and critical thinking skills. Inquisitive, analytical, laboratory technique familiarity, enthusiasm to learn and contribute in a fast-paced environment. Preferred Qualifications: Background in CRISPR gRNA development. Authorization to work in the United States indefinitely without restriction or sponsorship. The position is full-time, Monday-Friday, 8am-5pm with overtime as needed. Candidates living within a commutable distance of Boston, MA are encouraged to apply. Excellent full-time benefits include: Comprehensive medical coverage, dental, and vision options Life and disability insurance 401(k) with company match Paid vacation and holidays Eligibility for yearly goal-based bonus & merit-based increases Compensation: $32.00-$41.00 per hour Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer. The work we do at Eurofins Professional Scientific Services matters, and so do our employees. At Eurofins PSS, we put a focus on your professional growth. We provide our employees the ability to break into the biopharmaceutical industry and grow from the bottom up. We have the supportive teams and tools available to invest in you while also affording you work-life balance and a competitive benefits package. Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies. If you’re looking for a rewarding career, a place to call home, apply with us today!