Late-Stage LNP Process Development Scientist

Job description

As a member of the Late-Stage LNP Process Development team, the candidate will be joining a team conducting laboratory studies to support the process development, process scale-up, and process characterization of LNP clinical stage drug products. The successful candidate will have experience with LNP process development (having additional experience in tech transfer and GMP manufacturing is a plus but not required), and a desire to contribute to a team focused on establishing science-based manufacturing solutions for complex nucleic acid-based drug products. In this highly collaborative and cross-functional role, the candidate will support the refinement of process control and improve process understanding for multiple programs at various stages of clinical development. Support routine process development and process characterization activities centered around the LNP drug product manufacturing process. Batch ranges vary from 10 mg to 1 gram. Execute routine analytics including dynamic light scattering (DLS), UV-quantification via Ribogreen®, pH, and osmolality for in-process monitoring. Perform experiments under limited to no supervision under subject matter expert guidance. Organize and analyze data, interpret results, and present findings within the process development team and cross-functionally. Author technical documentation (SOPs, reports, protocols) as required. Document experiments and protocols using electronic lab notebooks (e.g., Benchling). Maintain laboratory equipment, order critical reagents, and support operational excellence activities. Minimum Required Qualifications: B.S. degree in chemical/biomedical engineering, chemistry, or biological sciences (or related field) with 3-4 years of relevant laboratory experience. M.S. degree in biological or biochemical sciences (or related field) with 1-2 years of relevant laboratory experience. Proficiency in bench-scale drug product manufacturing of LNPs with a focus on mixing and tangential flow filtration (TFF) processes. Experience with practices and equipment used in process development of nucleic acids (experience with T-mixing and TFF is preferred). Experience with DLS and osmolality for in-process monitoring. Experience working with ELN systems such as Benchling. Experience with technical documentation (SOPs, technical reports, protocols). Ability to follow established SOPs for routine analytics. Ability to achieve results, keep to a timeline, and find solutions to ensure that overall project deliverables are met. Strong attention to detail, analysis of data/reports, troubleshooting, and problem-solving abilities. Strong writing and communication skills with the ability to understand and communicate scientific information. Strong organizational and time management skills. Willingness to collaborate with cross-functional teams. Proactive, creative, and positive attitude. Preferred Qualifications: Experience with UV-quantification via Ribogreen®. Experience with GMP manufacturing practices and tech transfer operations is a plus. Experience with statistical analysis software (i.e. JMP, Design Expert, etc.) is a plus. Authorization to work in the United States indefinitely without restriction or sponsorship. The position is full-time, Monday-Friday, 8am-5pm with overtime as needed. Candidates living within a commutable distance of Boston, MA are encouraged to apply. Excellent full-time benefits include: Comprehensive medical coverage, dental, and vision options Life and disability insurance 401(k) with company match Paid vacation and holidays Eligibility for yearly goal-based bonus & merit-based increases Compensation: $36.00-$41.00 per hour Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer. The work we do at Eurofins Professional Scientific Services matters, and so do our employees. At Eurofins PSS, we put a focus on your professional growth. We provide our employees the ability to break into the biopharmaceutical industry and grow from the bottom up. We have the supportive teams and tools available to invest in you while also affording you work-life balance and a competitive benefits package. Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies. If you’re looking for a rewarding career, a place to call home, apply with us today!