Manager, CMC Project Management

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies as single agents and as part of combination regimens to treat a range of solid tumors. For more information, visit [](https://nam13.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.globenewswire.com%2FTracker%3Fdata%3DiRbGFgYP6ltuiKaWJMN-VqRAUqbWyUxrmINzdOIECYaBWd3lJ0VJpvt0RztrdQbPeHwI5phjZuWBlxxP81IIOhkFOP51sIbw1UZv0ra8-eTDPRGUAn7Q1_5TPXufY0ZK&data=05%7C02%7Ckristy.cobill%40crescentbiopharma.com%7C3a4262d820fa463f09da08ddad2d1944%7Cea3ae1e37f5f46159580d5c6e0711b3c%7C0%7C0%7C638857131411125658%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=20GPURqhaN9PyX5kPzV9huwRgWvPYrjlitHt8f8lCWA%3D&reserved=0 "") and follow the Company on [LinkedIn](https://nam13.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.globenewswire.com%2FTracker%3Fdata%3DZynOklBsETaAfH9zH2DZEKtm2QIV5CK8UcnS9y6rRnnBoDmbzTBHYckQrAowGdQcF-vO51wYRLIdTpjropqMIuGZKs71FyBQHIO36f-i6NPlEJYQr6TqZo7-QL09KdaK&data=05%7C02%7Ckristy.cobill%40crescentbiopharma.com%7C3a4262d820fa463f09da08ddad2d1944%7Cea3ae1e37f5f46159580d5c6e0711b3c%7C0%7C0%7C638857131411150941%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=QbTAUqmmjbU837K8weJfxn32FaezBQe0bts0p4xsfow%3D&reserved=0 "") and [X.](https://nam13.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.globenewswire.com%2FTracker%3Fdata%3D3__lb7yjpqgEJ82HQ24CTgcOho5ccwJkXdDrHXdzjIaCIyyAeau0lTzX4YedcsQ3ox_RgjYQLcRTGAuNCsS_vw%3D%3D&data=05%7C02%7Ckristy.cobill%40crescentbiopharma.com%7C3a4262d820fa463f09da08ddad2d1944%7Cea3ae1e37f5f46159580d5c6e0711b3c%7C0%7C0%7C638857131411169359%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=awcJCwsV7hPJUS%2Fy9ynDZhEXNbcC3i3QToEEGObUxIY%3D&reserved=0 "") We are seeking a Manager, CMC Project Management who isresponsible for driving cross-functional execution of CMC activities in support of early and late-stage clinical development programs. Working closely with Technical Operations - including Drug Substance, Drug Product, Analytical Development, Regulatory CMC, Quality, Supply Chain and external partners, this role leads integrated project planning, facilitates cross-functional alignment, manages risks and timelines, and enables successful delivery of CMC milestones in support of regulatory and development objectives. **This role is based in Waltham, MA and you must have experience in the oncology space.** ### Responsibilities - Lead cross-functional CMC project management for clinical-stage development programs, developing and maintaining integrated project plans, timelines, critical path activities, milestones, risks, and decision logs. - Drive project execution by facilitating cross-functional meetings, tracking actions and decisions, proactively identifying risks and dependencies, and escalating issues to ensure program objectives are achieved. - Coordinate activities across Drug Substance, Drug Product, Analytical Development, Quality Control, Quality Assurance, Supply Chain, Regulatory CMC, and other Technical Operations functions to ensure alignment of priorities and deliverables - Partner with CDMOs, CROs, testing laboratories, and other external vendors to monitor deliverables, manufacturing activities, timelines, and issue resolution. - Coordinate planning and execution of CMC regulatory submissions, including INDs, IMPDs, amendments, and health authority responses, ensuring cross-functional deliverables are completed on schedule. - Support program budgeting, forecasting, resource planning, purchase order tracking, and financial reporting to enable effective execution of CMC development activities. - Identify and implement process improvements to strengthen CMC project execution, governance, resource planning, and organizational effectiveness. ### Education & Experience - Bachelor’s degree in a scientific, engineering, or related discipline required. - 5–8 years of biotech or pharmaceutical industry experience. - Experience in CMC, Technical Operations, Project Management, Manufacturing, Supply Chain, or related functions. - Familiarity with GMP manufacturing and external partner management. - Strong project management and organizational skills. - Ability to manage multiple priorities in a fast-paced environment. - Excellent communication and collaboration skills. - Experience with project planning and tracking tools. - Ability to identify risks and drive issue resolution. - Detail-oriented with strong follow-through and accountability ### What We Offer - Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment - Competitive compensation, including base salary, performance bonus, and equity - 100% employer-paid benefits package - Flexible PTO; also, two, one-week company-wide shutdowns each year - A commitment to your professional development, with access to resources, mentorship, and growth opportunities