Manager, IT Infrastructure & Operations

amylyx

Cambridge, MA · Cambridge · United States

Posted Jul 24, 2026

Other
Remote
550 - IT

Job description

Amylyx has an audacious mission to usher in a new era for treating diseases with high unmet needs. Where others see challenges, we see opportunities that we pursue with urgency, rigorous science, and unwavering commitment to the communities we serve. We are a clinical-stage company currently focused on post-bariatric hypoglycemia (PBH), Wolfram syndrome, and amyotrophic lateral sclerosis (ALS).

Our mission is powered by our people. Our core values – be audacious, be curious, be authentic, be engaged, and be accountable – creating a culture of caring. Amylyx has assembled an experienced team ready to take action because the communities we serve have no time to wait. If you share our passion and are determined to tackle some of medicine’s toughest problems, we encourage you to read the opportunity below and apply.

The Opportunity

Amylyx is seeking an experienced IT professional to support our growing organization. This role requires strong technical expertise, a customer-focused mindset, and the ability to serve as the primary point of contact for IT escalations and resolutions. As a key representative of the IT team, this individual will provide responsive, high-quality support to employees across the organization.

Responsibilities

Provide responsive IT support to all users and resolve escalated issues.
Deliver first- and second-level support through in-person, phone, and remote channels; document issues, resolutions, and service requests in the Service Management system.
Serve as the escalation point for external support partners on technical issues.
Coordinate scheduled and ad hoc software, system, and infrastructure deployments during business and non-standard hours.
Manage and optimize core ITIL service operations, including incident, event, request, problem, and access management.
Partner with Amylyx departments to deliver a consistent, high-quality user experience.
Support desktop imaging, applications, system administration, configuration, and supplier management, including hosted solutions.
Train employees and contractors on IT policies, procedures, and support practices.
Develop and maintain clear documentation for IT operational processes.
Configure, validate, and implement IT systems and services.
Administer SharePoint Online sites, permissions, libraries, governance standards, and user support to enable secure and effective collaboration.
Serve as the primary onsite, in-office IT support resource for local technology needs, including conference room systems and equipment.

Required Qualifications

Bachelor's degree with 5+ years of experience, or 8+ years of experience in customer-facing technical support or a similar role.
3+ years of experience in a pharmaceutical, biotech, or clinical research environment supporting clinical trials.
Demonstrated knowledge of Azure/Entra ID and Office 365.
Experience managing cloud infrastructure for a distributed workforce.
Knowledge of office and laboratory applications, hardware, and equipment.
Strong technical background supporting Windows, macOS, iOS, iPadOS, and cloud applications.
Experience supporting telephony and mobile technologies, including Android and iOS.
Exceptional organizational skills with the ability to manage multiple priorities and maintain strong attention to detail.
Collaborative team player with strong communication and problem-solving skills.
Highly motivated and adaptable, with strong interpersonal and leadership skills.
Willing and able to provide global on-call support for employees.
Ability to work onsite in Cambridge, MA

Work Location and Conditions

You will be expected to be onsite at our corporate location in Cambridge, MA three times per week.
When working remote, you must have access to work in setting which enables meeting all requirements of the role (including privacy, reliable internet access, phone, ability to video conference, etc.).

Compensation

The pay range posted below represents our good faith estimate of compensation for this role, based on market data and internal benchmarks. The final offer may vary depending on a candidate’s experience, skills, and qualifications, as well as considerations of internal equity.

Estimated Pay Range

$129,000—$145,000 USD

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Amylyx Pharmaceuticals is an Equal Opportunity Employer that does not discriminate on the basis of actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, pregnancy-related conditions, and lactation), gender identity or expression (including transgender status), sexual orientation, marital status, military service and veteran status, physical or mental disability, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances. Amylyx’s management team is dedicated to this policy with respect to recruitment, hiring, placement, promotion, transfer, training, compensation, benefits, employee activities, access to facilities and programs, and general treatment during employment. Accommodations are available for candidates who require them in our selection process. If you need an accommodation, please let your Amylyx Talent Acquisition contact know.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.