Population PK/Pharmacometrics Modeler- CDI- H/F

Job description

Who we are ? Pierre Fabre is the 2nd largest dermo-cosmetics laboratory in the world, the 2nd largest private French pharmaceutical group and the market leader in France for products sold over the counter in pharmacies. Its portfolio includes several medical franchises and international brands including Pierre Fabre Oncologie, Pierre Fabre Dermatologie, Eau Thermale Avène, Klorane, Ducray, René Furterer, A-Derma, Naturactive, Pierre Fabre Oral Care. Established in the Occitanie region since its creation, and manufacturing over 95% of its products in France, the Group employs some 10,000 people worldwide. Its products are distributed in about 130 countries. 86% of the Pierre Fabre Group is held by the Pierre Fabre Foundation, a government-recognized public-interest foundation, while a smaller share is owned by its employees via an employee stock ownership plan. In 2019, Ecocert Environment assessed the Group’s corporate social and environmental responsibility approach in accordance with the ISO 26000 sustainable development standard and awarded it the “Excellence” level. Pierre Fabre is recognized as one of the "World's Best Employers 2021" by Forbes. Our group is ranked in the Top 3 in the cosmetics industry and in the Top 10 in the pharmaceutical industry worldwide. Your mission We are seeking a Population PK/Pharmacometrics Modeler to join the Pharmacokinetics and Toxicology team within the Pierre Fabre R&D Pharma in Toulouse to support oncology programs (Langlade site, Oncopole). Who You are You are a proactive pharmacometrician who translates clinical trial data into strategic insights that shape dosing strategies, trial designs, and regulatory submissions. You combine deep technical expertise in population modeling with the ability to distill complex exposure-response relationships into clear recommendations for clinical teams, regulators, and senior leadership. You thrive in collaborative environments where your quantitative analyses directly influence decisions from Phase 1 dose escalation schemes to pivotal trial endpoints. You understand that the value of a model lies not in its mathematical elegance but in its ability to reduce uncertainty and accelerate patient access to effective therapies. Your role within a pioneering company in full expansion: Lead population PK/PD modeling strategies and translate findings into clear recommendations to drive critical decisions across clinical development programs Develop and qualify pharmacometrics analyses with emphasis on population PK/PD modeling and exposure-response analysis in oncology Drive and coordinate the integration of pharmacometrics analyses in the drug development process to mitigate risks early and support data-driven decision-making Identify opportunities where pharmacometrics analyses can contribute to a better understanding of pharmacokinetics, pharmacodynamics, safety, and efficacy Serve as lead author and key contributor for pharmacometrics sections of clinical and regulatory documents (e.g., briefing books, summaries of clinical pharmacology/efficacy/safety, and responses to Health Authority questions) Represent the team at global regulatory hearings/advisory committee meetings and other global regulatory interactions Mentor and guide colleagues on pharmacometrics methodology Contribute to scientific publication This position is compatible with teleworking up to 2 days a week according to company rules. We offer an attractive remuneration/benefits package: Incentives, profit-sharing, Pierre Fabre shareholding with matching contribution, health and provident insurance, 16 days of holidays (RTT) in addition to 25 days of personal holidays, public transport participation... Who you are ? Your skills at the service of innovative projects: Required Qualifications: PhD in Pharmaceutical Sciences, Pharmacometrics, Biostatistics, Applied Mathematics, or a related quantitative field Minimum 5+ years of hands-on population PK modeling experience in the pharmaceutical industry Expert-level proficiency in NONMEM; familiarity with other mixed-effects modeling tools, such as Monolix, is a plus Extensive experience with advanced population PK/PD methodology Strong programming skills in R or Python for data manipulation, exploratory analysis, diagnostics, and visualization Experience in supporting regulatory submissions (IND, NDA/BLA) including preparation of modeling sections and responding to health authorities Excellent interpersonal skills and the ability to work in cross-functional teams Excellent written and verbal skills in English Preferred Qualifications: Proven track record of delivering pharmacometrics analyses that influenced clinical development or regulatory decisions Experience with model-based meta-analysis, Bayesian trial design, or novel exposure-response methods Understanding of oncology drug development is highly desirable Experience in modeling multiple therapeutic modalities beyond small molecules (biologics, targeted therapies, ADCs) is a plus We are convinced that diversity is a source of fulfillment, social balance and complementarity for our employees, which is why our offers are open to all, without restriction.