Postdoctoral Fellow - Hyun Jung Kim Lab

At Cleveland Clinic Health System, we believe in a better future for healthcare. And each of us is responsible for honoring our commitment to excellence, pushing the boundaries and transforming the patient experience, every day. We all have the power to help, heal and change lives — beginning with our own. That’s the power of the Cleveland Clinic Health System team, and The Power of Every One. Job Title Postdoctoral Fellow - Hyun Jung Kim Lab Location Cleveland Facility Cleveland Clinic Main Campus Department Job Code X1004 Shift Variable Schedule 12:00am-12:00am Job Summary Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through Cleveland Clinic Research. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years. Compensation follows the NIH NRSA Postdoctoral Salary Scale based on total years of postdoctoral experience. Job Details NIH NRSA Postdoctoral Salary Scale Years of Experience: Stipend for FY 2026 0: $63,480 1: $63,900 2: $64,380 3: $66,948 4: $69,180 5: $71,748 6: $74,424 7 or More: $77,076 Biomimetic Microengineering (BioME) Lab (PI: Hyun Jung Kim, PhD) at the Cleveland Clinic has developed a human Organ-on-a-Chip that recapitulates the host-microbiome ecosystem to model various gastrointestinal (GI) diseases. By integrating patient-derived cells and microbes, we create a personalized Disease-on-a-Chip to uncover disease mechanisms and identify novel therapeutic strategies. We are seeking highly motivated Postdoctoral Researchers to join our interdisciplinary team to work on the following projects advancing innovation in translational science, engineering, and medicine. Principal Investigator: Hyun Jung Kim, PhD Cleveland Clinic Research Department: Inflammation and Immunity POSITION 1: Advanced Engineering for Multiscale Organ-on-a-Chip Platforms We are hiring dedicated candidates to advance our multiscale Organ-on-a-Chip platform, enabling scalable operations through multiple experimentation, configurable modules, and a cost-effective, reproducible design that supports strong reproducibility and replicability. The ideal candidate will have expertise in i) mechanical engineering and robotics, including precision mechatronics design for multi-scale laboratory experimentations with embedded automation, ii) 3D printing, rapid prototyping, and precision manufacturing processes for multiscale hardware development, and iii) microfluidics, microfabrication, or microengineering to integrate an engineered system with microscale biological models and implement automated system control. POSITION 2: Microbiome-Associated Anti-Cancer Therapeutics in Organ-on-a-Chip Platforms We seek postdoctoral researchers to investigate how gut microbes modulate immune checkpoints on colorectal cancer (CRC) cells. Using patient-derived CRC organoid models, we have demonstrated that live gut bacteria reduce the expression of surface immune checkpoints through an enzymatic mechanism. Successful candidates will identify the responsible microbial enzymes and elucidate their mechanism of action. Strong candidates will have expertise in one or more of the following: microbial biochemistry and enzymology; glycobiology and carbohydrate-active enzymes (CAZymes); proteomics-based target identification; protein engineering; or microbial synthetic biology. Experiences in engineering designer probiotics or liver biotherapeutics for targeted payload delivery or tumor-localized sensing are highly desirable. Candidates trained in host-microbiome biochemical interactions, glycoprotein processing, microbial physiology, or AI-assisted synthetic biology are especially encouraged to apply. Skills Required: Candidates must have rigorous scientific training in research design and analysis. A strong track record of previous research achievements is highly valued. Ideal candidates should demonstrate expertise in at least one of the following areas: i) human microphysiological system (MPS) or 3D bioprinting, ii) mechanical engineering, device design and manufacturing, system automation, or mechatronics engineering, iii) iPSC-based tissue engineering, iv) GI mucosal biology, cancer biology, or cancer immunology, or v) clinical microbiology and host-microbiome interactions. For more information about the lab's research, please visit or contact Dr. Kim at Job Responsibilities: Mechanical engineering and robotics, including precision mechatronics design for multi-scale laboratory experimentations with embedded automation 3D printing, rapid prototyping, and precision manufacturing processes for multiscale hardware development Microfluidics, microfabrication, or microengineering to integrate an engineered system with microscale biological models and implement automated system control Education: PhD or MD/PhD required MD with relevant laboratory experience may substitute for PhD Languages: English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status Work Experience: Previous experience in a research or academic setting. Graduate student experience meets this requirement. Scientific writing experience Additional Preferred Qualities: Enzymology; glycobiology and carbohydrate-active enzymes (CAZymes) Proteomics-based target identification; protein engineering Microbial synthetic biology, engineering designer probiotics or live biotherapeutics for targeted payload delivery or tumor-localized sensing Host-microbiome biochemical interactions, glycoprotein processing, microbial physiology, or AI-assisted synthetic biology Physical Requirements: Ability to perform work in a stationary position for extended periods Ability to operate a computer and other office equipment Ability to communicate and exchange accurate information Ability to distinguish color Manual dexterity to handle specimens and repair equipment Ability to lift and transport equipment or specimens weighing up to 20 pounds May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc. Personal Protective Equipment: PPE per institutional requirements; may vary by laboratory Preferred Application Materials: Applicants are required to send i) CV and ii) Cover Letter to . In the cover letter, please highlight the qualifications pertinent to the project outlined in the job description and a list of 3 references. Keywords: Postdoc, Research, mechanical engineering and robotics, 3D printing, rapid prototyping, and precision manufacturing processes, microfluidics, microfabrication, or microengineering, microbial biochemistry and enzymology, glycobiology The policy of Cleveland Clinic Health System and its system hospitals (Cleveland Clinic Health System) is to provide equal opportunity to all of our caregivers and applicants for employment in our drug free environment. All offers of employment are followed by testing for controlled substances. Cleveland Clinic Health System administers an influenza prevention program. You will be required to comply with this program, which will include obtaining an influenza vaccination on an annual basis or obtaining an approved exemption. Decisions concerning employment, transfers and promotions are made upon the basis of the best qualified candidate without regard to color, race, religion, national origin, age, sex, sexual orientation, marital status, ancestry, status as a disabled or Vietnam era veteran or any other characteristic protected by law. Information provided on this application may be shared with any Cleveland Clinic Health System facility. If applying for a Florida position, please see the following website for more information on the background screening requirements required by the Agency of Health Care Administration: Please review the Equal Employment Opportunity poster . Cleveland Clinic is pleased to be an equal employment opportunity employer.