Principal Scientist, ADCs Discovery Biology, Oncology Thematic Research Center

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. We are seeking a creative and driven scientist to join our expanding ADC Discovery team and play an important role in advancing next-generation oncology therapeutics. As a Principal Scientist, you will independently lead antibody-drug conjugate (ADC) drug discovery programs from target concept to IND filing, leveraging proprietary technologies and collaborating with top experts in the field. The qualified candidate should be a highly motivated, independent, and collaborative scientist capable of leading cross-functional teams and executing rigorous biology programs across a highly matrixed organization. Our team thrives on creativity, rigorous science, and a shared commitment to transforming cancer care. In the role as a Principal Scientist within Discovery Biology, the ideal candidate will: - Lead highly matrixed ADC discovery teams from target concept to IND and lead/mentor a biology team supporting in vitro experimentation - Leverage current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates - Apply extensive technical knowledge to address ADC mechanisms of action, including evaluating novel payload classes and linker strategies - Collaborate with functional area leads (e.g., pharmacology, DMPK, bioinformatics, informatics and predictive science) to drive programs forward, including helping to define program priorities and risks - Work with bioinformaticians and translational research scientists to design and execute studies supporting patient stratification and identification of appropriate target engagement PD markers - Present complex scientific concepts to a range of audiences including governance committees and full team project meetings - Communicate findings and progress clearly and effectively via email, written reports, and scientific presentations - Mentor and develop junior scientists within the team, fostering a collaborative and scientifically rigorous environment **Basic Qualifications:** - Bachelor’s Degree and 8+ years of academic and / or industry experience Or - Master’s Degree and 6+ years of academic and / or industry experience Or - Ph.D. or equivalent advanced degree in the Life Sciences and 4+ years of academic and / or industry experience **Preferred Qualifications** - Ph.D. or equivalent advanced degree in the Life Sciences with 4+ years of industry experience in oncology drug discovery - Hands-on experience in the design, development, and optimization of high-throughput cell-based assays for antibody screening and ADC activity - Experience profiling and developing complex biologics (e.g., bispecifics, biparatopics, masked antibodies) - Experience with linker-payload design and evaluation, including both cytotoxic and targeted payload classes - Experience contributing to an IND filing - Developing leadership skills with demonstrated ability to lead, coach, and mentor a team of lab-based in vitro biologists - Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work - Ability to summarize and interpret complex scientific data in a clear, concise, and accurate manner - Excellent oral and written communication skills, with the ability to communicate effectively with peers, supervisors, and governance committees - Strong problem-solving skills and sound understanding of complex scientific principles - Demonstrated experience leveraging AI and data-driven tools to support scientific decision-making and program planning #LI-ONSITE We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway. ******Compensation Overview:****** Cambridge Crossing: $156,180 - $189,252 The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance. **Benefits:** Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability). U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year. Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays. Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day. U.S.-based job seekers can explore full benefit offerings at **How We Work** Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at [](https://careers.bms.com/life-at-bms/ways-of-working/) **Supporting People with Disabilities** BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [adastaffingsupport@bms.com](mailto:adastaffingsupport@bms.com). Visit [](https://careers.bms.com/eeo-accessibility) to access our complete Equal Employment Opportunity statement. **Candidate Rights** BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: **Data Protection** We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at [](http://careers.bms.com/fraud-protection). Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations. 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