Principal Scientist, Biologics Optimization

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Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Biotherapeutics R&D Job Category: Scientific/Technology All Job Posting Locations: Spring House, Pennsylvania, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at We are searching for the best talent for Principal Scientist, Biologics Optimization in Spring House, PA Purpose: The Biologics Optimization team within Biologics Discovery is responsible for the design and optimization of lead biologic variants across multiple therapeutic modalities to achieve differentiated functional outcomes aligned with desired therapeutic mechanism of action (MoA). In this position, the Principal Scientist will serve as a scientific leader and subject matter expert in biologics optimization, driving and dissecting engineering strategies that translate molecular design into improved biological function across diverse therapeutic modalities. The Principal Scientist I will be an integral member of the Biologics Optimization team that works on the cutting edge of protein science and technologies to deliver fit-for-purpose optimized protein sequences supporting the therapeutic pipeline. This role requires deep expertise in antibody and protein engineering, display-based technologies, computational and AI/ML-enabled design approaches, and mechanism-driven biologics discovery. The successful candidate will partner closely with Therapeutic Area scientists, computational scientists, protein engineers, and drug discovery teams to develop and implement optimization strategies that enhance potency, selectivity, efficacy, and overall therapeutic performance. The Principal Scientist will be expected to establish and champion scientific best practices in function-driven optimization, leveraging detailed understanding of antibody structure-function relationships, protein sequence space, and biological pathways to guide engineering decisions. This role offers the opportunity to influence discovery programs across the portfolio while shaping future optimization capabilities and technologies within Biologics Discovery. This role offers an exciting opportunity to not only engage in the discovery and molecular engineering of biotherapeutics, but also develop new processes and technologies in collaboration with other functional groups. This Principal Scientist I will have the opportunity to lead project teams and interact seamlessly with world-class Therapeutic Area scientists. You will be responsible for: Lead biologics optimization efforts across multiple therapeutic programs, translating target biology and desired mechanisms of action into rational protein engineering strategies. Serve as a subject matter expert in function-driven optimization: develop and champion novel development efforts aimed at fulfilling strategic long-term antibody design/optimization initiatives and validation. Develop optimization strategies that integrate antibody sequence, structure, developability, and biological function to achieve program objectives. Lead/participate on project teams to advance discovery portfolio projects. Act as a point of accountability for optimization engineering asks and manage project timelines independently. Partner with teams across TD/TA to define critical functional hypotheses and establish screening cascades that enable MoA-driven decision making. Apply computational, AI/ML, and data-driven approaches to guide variant design, library construction, sequence prioritization, and hit selection. Evaluate emerging technologies and develop innovative approaches to accelerate biologics optimization workflows and therapeutic discovery. Independently present/defend scientific findings in multi-functional project teams/initiatives. Independently plan, analyze and interpret experimental results and draft patent applications, manuscripts, protocols, SOPs, technical reports, etc. Qualifications / Requirements: Education: A minimum of a MS Degree in in Molecular Biology, Biochemistry, Biotechnology, Biomedical Engineering, structural biology or related field is required. PhD is highly preferred. Skills/Experience Required: A minimum of 3 years of relevant industry experience in biologics discovery, protein engineering, or therapeutic optimization is required. Demonstrated scientific leadership and expertise in biologics optimization with a strong focus on improving functional outcomes aligned with therapeutic mechanisms of action. Extensive experience in antibody and protein engineering with a demonstrated ability to advance therapeutic molecules through optimization cycles. Deep understanding of antibody structure-function relationships, including variable region architecture, framework and CDR design, sequence liabilities, affinity maturation, specificity engineering, and developability considerations. Hands-on experience with display-based technologies for protein engineering and optimization, with preference for yeast display and/or mammalian display platforms. Strong understanding of therapeutic biology and demonstrated experience applying biological insights to address function-driven engineering challenges. Proven ability to evaluate therapeutic mechanisms of action and design optimization strategies that improve biological activity, efficacy, selectivity, or target engagement. Strong understanding of biophysical and biochemical methods used for antibody and protein characterization, including techniques such as SPR, ELISA, flow cytometry, thermal stability analysis, aggregation assessment, and other developability metrics. Experience leveraging AI/ML, computational biology, protein modeling, or data science approaches to support biologics optimization and engineering workflows. Zeal for addressing complex scientific questions and solving novel challenges with creativity and a collaborative spirit. Demonstration of successful implementation of new ideas with calculated risk taking. Abilities to lead by influence and communicate across teams with diverse backgrounds is required. Demonstration of clear, concise, and timely communication skills, exemplified by peer-reviewed publications is required. Preferred: Candidates with a Master’s degree: 6 years of industry experience is preferred Candidates with a PhD: 3 years of industry experience is preferred Expertise in scientific computing (e.g. Python) and experience with in silico protein structure and sequence modeling using AI/ML methods to facilitate collaboration with computational and AI/ML functional teams Expertise in protein structure modeling and visualization tools such as Schrödinger, MOE, PyMOL, Chimera, or AlphaFold-based workflows. Hands-on experience with cell-based functional assays across oncology or immunology areas (e.g. T-cell redirection, immune modulation) Hands-on experience with high-throughput binding assays and screening technologies, including ELISA, SPR, MSD, flow cytometry, or related platforms. Strong understanding of mammalian protein expression systems, including transient expression and recombinant protein production workflows. Experience integrating large-scale experimental datasets with computational and AI/ML approaches to accelerate optimization decisions. Demonstrated ability to establish new scientific capabilities, influence strategy, and mentor scientists within a matrixed research environment. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource. If you are under 18 years of age you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check. Required Skills: Preferred Skills: