Principal Scientist, Imaging Analytics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. Job Function: Data Analytics & Computational Sciences Job Sub Function: Data Science Job Category: Scientific/Technology All Job Posting Locations: Cambridge, Massachusetts, United States of America, New Brunswick, New Jersey, United States of America, Raritan, New Jersey, United States of America, Spring House, Pennsylvania, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at We are seeking a Principal Scientist, Imaging Analytics to join Interventional Oncology (INTO) and lead the scientific application of medical imaging Artificial Intelligence across our early-phase oncology portfolio. In this role, you will transform routinely collected oncology trial scans (CT, MRI, PET) into earlier, evidence-based clinical-development decisions. You will advance foundational imaging-AI capabilities, develop novel quantitative imaging metrics, and deliver insights that enhance response assessment, dose optimization, and go/no-go decisions. This is a high-impact, high-visibility role for a scientist who is passionate about translating cutting-edge imaging AI from research into real-world clinical impact. You will serve as a scientific bridge across data science, clinical development, and external partners. This position can be based in New Brunswick/Raritan, NJ; Spring House/Horsham, PA; or Boston, MA. Key Responsibilities Lead end-to-end AI applications on trial imaging data (CT, MRI, PET) for quantitative imaging measures and AI-derived endpoints. Collaborate internally and externally to drive scientific innovation in foundational imaging AI that are relevant to oncology drug development — including automated segmentation, radiomics, and multimodal predictive modeling through hands-on research. Translate imaging-derived evidence into actionable insights by converting complex quantitative findings into clear scientific narratives and engaging cross-functional stakeholders Provide scientific leadership to external partnerships — including imaging AI vendors, CROs, biomarker companies, academic centers, and imaging OEMs — to accelerate model development, validation, and deployment. Publish and present scientific innovation at top scientific and clinical conferences (e.g., MICCAI, AACR, RSNA, etc.) Required Knowledge, Skills and Abilities : Ph.D. in Computer Science, Biomedical Engineering, Electrical Engineering, or a related quantitative field. 3+ years of post-doctoral or industry experience developing AI/ML for medical imaging (CT, MRI, PET) in a clinical setting. Hands-on expertise across the medical imaging AI stack: deep learning (segmentation, detection, classification, registration), radiomics, and multimodal predictive modeling. Proficiency in Python and PyTorch, with practical experience in medical-imaging libraries such as MONAI, SimpleITK, ITK, PyRadiomics, nnU-Net, 3D Slicer, and OpenCV. Experience with cloud ML infrastructure and MLOps practices for scalable training and inference on imaging data. Extensive experience with the full imaging data workflow: DICOM I/O, visualization, registration, harmonization, annotation, and segmentation of 3D medical images. Strong peer-reviewed publication record and demonstrated ability to communicate complex scientific concepts to both technical and cross-functional audiences. Preferred: Experience in analyzing solid-tumor imaging, particularly lung and head & neck (H&N). Track record of developing and applying AI/ML to oncology imaging and within oncology clinical trials. Familiarity with standard oncology endpoints (e.g., RECIST 1.1, iRECIST, PERCIST). Experience building and scaling clinical or imaging AI platforms end-to-end, including data ingestion, harmonization, model inference, visualization, and continuous monitoring. Experience in sourcing, structuring, and managing external partnerships with imaging-AI vendors, CROs / imaging core labs, biomarker companies, and academic centers. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource. #LI-GR1 #LI-Hybrid #JRDDS #JNJDataScience #JRD Required Skills: Preferred Skills: Advanced Analytics, Coaching, Critical Thinking, Data Analysis, Data Privacy Standards, Data Quality, Data Reporting, Data Savvy, Data Science, Data Visualization, Digital Fluency, Econometric Models, Organizing, Process Improvements, Strategic Thinking, Technical Credibility, Workflow Analysis The anticipated base pay range for this position is : $117,000.00 - $201,250.00 Additional Description for Pay Transparency: Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation –120 hours per calendar year Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year Holiday pay, including Floating Holidays –13 days per calendar year Work, Personal and Family Time - up to 40 hours per calendar year Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year Caregiver Leave – 80 hours in a 52-week rolling period10 days Volunteer Leave – 32 hours per calendar year Military Spouse Time-Off – 80 hours per calendar year For additional general information on Company benefits, please go to: -