Research Associate II, High-Throughput Cell Biology

Job description

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere. ## The Team Our decoding inflammation team builds tools to enable precise molecular-level measurements of inflammation within human tissues in real time, and develop proactive, early interventions that can be deployed when inflammation — which underlies the most significant causes of death worldwide — first flares in the body. You can learn more about our work [here](https://biohub.org/inflammation/). Our team collaborates with three powerhouse universities - Northwestern University, the University of Chicago, and the University of Illinois Urbana-Champaign - to develop first-in-class technologies and make breakthroughs. **Our Vision** - Pursue large scientific challenges that cannot be pursued in conventional environments - Enable individual investigators to pursue their riskiest and most innovative ideas - Facilitate research by scientists and clinicians at our home institutions and beyond We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease. ## The Opportunity To support our AI models and applications in inflammation and immunology, Biohub Chicago is building a lab that runs biology experiments at a scale and consistency that manual work can't reach. We are seeking a Research Associate experienced in hands-on cell biology to work closely with automation engineers and scientists, performing consistent cell maintenance, executing experiments on and off automated systems, and developing the QC metrics which will form the basis for a reliable experimentation platform. We are looking for a strong experimentalist who is comfortable learning new instrumentation. ## What You'll Do - Support execution of high throughput experiments, including loading labware, reagents, performing startup and shutdown operations, and monitoring execution to flag for deviations to planned protocol. - Perform routine cell culture and molecular biology, including daily bulk cell culture maintenance, media preparations, and routine equipment maintenance tasks. - Assist in model development and maintenance, including culture and differentiation of iPSCs or other relevant cell systems that recapitulate disease-related phenotypes. - Design, optimize, and troubleshoot experimental protocols and SOPs, proactively identifying bottlenecks and opportunities to improve throughput, reliability, or efficiency. - Maintain detailed lab notebooks, document experimental outcomes, and Communicate findings to the larger team. - Independently plan, prioritize and execute work. - Collaborate with scientists in experimental design and analysis. - Adhere to laboratory safety standards, guidelines, and protocols. ## What You'll Bring - Master's or Bachelor’s degree in Biological Sciences or a related field - 2-4 years of hands-on research experience - Experience culturing primary cells, non-adherent cells as well as immortalized cell lines - Flexibility and willingness to learn new technologies - Strong organizational skills and attention to detail across multi-step, multi-day experimental workflows — including documentation, reagent management, and coordination - Ability to work independently on assigned projects Nice to Have - Experience with flow cytometry, including sample preparation and instrument operation - Experience with next-generation sequencing library preparation or single-cell genomics platforms (particularly 10x Genomics) - Familiar with lentiviral vector productions and transduction - Experience culturing iPSCs - Experience with lab automation and liquid handling ## Compensation The Chicago, IL base pay range for a new hire in this role is $70,000 - $87,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role. ## **Benefits for the Whole You** We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. - Provides a generous employer match on employee 401(k) contributions to support planning for the future. - Paid time off to volunteer at an organization of your choice. - Funding for select family-forming benefits. - Relocation support for employees who need assistance moving If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role. #LI-Onsite