Research Associate / Senior Research Associate, Lead Discover

**About Treeline** Treeline Biosciences is an innovative biotechnology company, founded by an experienced team of biopharmaceutical scientists and executives, committed to developing innovative medicines against difficult to drug targets in cancer and other life-threatening diseases. We employ an aggressive, integrated approach that applies modern and emerging tools in lead discovery, medicinal chemistry, antibody-drug conjugates, and computation to reduce the time and risks of drug discovery. **About the Role** We are seeking a highly motivated and experienced Research Associate to join our Watertown, MA team to support the drug discovery projects and exploration, delivering high-quality scientific data and insights to drive small molecule drug discovery. Specifically, this position will carry out and optimize crystallography and biophysical experiments alongside colleagues within both the multi-disciplinary Lead Discovery organization across biophysics, biochemistry, structural biology, and protein production, as well as the broader research and development organization including biology, computational chemistry, and medicinal chemistry. The ideal candidate will take a lead on lab equipment operation/maintenance, execute on structural experiments, and effectively communicate results to colleagues within Lead Discovery and project teams. **Responsibilities:** - Become a key contributor to our internal Structural Biology and Biophysics teams, supporting our capability to provide both routine and novel insights to multiple drug programs. - Work with Treeline Lab Operations staff and external vendors to ensure smooth laboratory operations. - Collaborate with other members of the Lead Discovery team (protein sciences, biochemistry, mass spectometry) to characterize small molecule ligand binding and establish SAR. **Qualifications:** - BS./M.S. degree in a scientific or technical field related to biology, biochemistry, or chemistry and 2+ years work experience in life sciences sector. - Ability to maintain and operate sensitive lab equipment, like liquid handlers, automated imagers, and microscopes. - General laboratory experience and knowledge: pipetting, preparing buffer solutions, etc. - Ability to work efficiently and deliver detailed results within defined timelines and to collaborate in a multidisciplinary team. - Experience with protein expression or protein activity and binding assays. - Preference for candidates with industry experience or academic training in some aspects of the X-ray crystallography workflow (setting screens, crystal optimization and harvesting) and biophysical characterization of protein or small molecule interactions (SPR, BLI, MST, ITC, etc). - Working knowledge of a Linux computation environment and/or Shell/python scripting is a plus. - Enthusiasm for science and working in a team environment that values good work and rapid progress. *This position is classified as exempt. The anticipated annual base salary range for candidates who will work in Watertown is $92,173 - $106,882. The final base salary offered to the successful candidate will be dependent upon several factors that may include but are not limited to the type and length of experience within the job, and other factors. Treeline Biosciences is a multi-state employer, and this salary range may not reflect positions that work in other cities or states.* ***Recruitment fraud statement*** ***Please be aware of recruitment fraud and related job scams, where scammers present themselves as recruiters but are seeking to steal money or personal information. Keep the following in mind to protect yourself:*** - ***Treeline Biosciences will never ask for money from you as part of our recruitment process. Do not provide bank details or pay somebody for the promise of a job at Treeline.*** - ***We do not conduct interviews through RingCentral, Skype or Telegram.*** - ***Our job openings are first posted to . If you locate a listing for a Treeline job on another site, please ensure it is also posted on our careers website.*** - ***You can find more information about job scams at - ***To report job scams, head to .*** ## Notice to Search Firms/Third-Party Recruitment Agencies (Recruiters) The Human Resources team manages the recruitment and employment process for Treeline Biosciences. To protect the interests of all parties involved, Treeline Biosciences will only accept resumes from a recruiter if an executed search agreement directed to the particular position or positions is in place at the start of the recruitment effort. Unsolicited resumes sent to Treeline Biosciences from recruiters do not constitute any type of relationship between the recruiter and Treeline Biosciences and do not obligate Treeline Biosciences in any way to pay fees should we hire from those resumes. Recruiters are requested not to contact or present candidates directly to our hiring manager or employees.