Research Scientist, Cellular Physiology

Job description

**About Nudge** At Nudge, our mission is to develop the best technology for interfacing with the brain to improve people's lives. We're starting with an approach that we believe can help the most people the fastest, and also allow us to learn as much about the brain as possible: developing a non-invasive, ultrasound-based device that can stimulate and image the brain at high resolution and depth. This is a vertically integrated effort building cutting-edge hardware, software, and research capabilities to create products that can benefit millions — and eventually billions — of people. To succeed, we need to assemble world-class teams across everything we do. We hire people who are exceptional at their craft, believe hard things are worth doing, and execute relentlessly — people who expect the highest levels of both rigor and integrity from each other. **About the role** As a research scientist focused on cellular physiology at Nudge, you will: - Develop methods for characterizing the mechanisms of action of ultrasound on neural tissue - Design and execute experiments in vitro to determine the impact of ultrasound on cellular properties, activity, and plasticity - Explore ultrasound parameter optimization for driving cellular activity and plasticity - Translate in vitro findings to inform human neuromodulation studies **About you** We are looking for research scientists of all levels but regardless of your career level, you should have: - A PhD or postdoc in neuroscience, molecular/cellular biology, biomedical engineering or a similar engineering discipline - Exceptional proficiency in neuronal cell culture, including human iPSC-derived neurons, and slice methods - Experience applying advanced microscopy techniques (e.g., two-photon calcium imaging), electrophysiology, or other neural recording techniques to characterize cellular and synaptic physiology - Experience developing or using genetic tools (viral transduction, CRISPR-based approaches, etc.) for molecular manipulations in neural tissue - A demonstrated history of exceptional technical contribution - High integrity and strong professional judgement - A high level of independent thinking and relentless execution approach