Scientist - DMPK

Job description

Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays) Support development and validation of new ADME assays to expand the group’s scientific capabilities Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex) Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics Master's in Lifescience with 7+ years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc. Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding Ability to troubleshoot experimental challenges and apply sound scientific judgment Self-driven and capable of managing multiple tasks while working within demanding project timelines Strong attention to detail and commitment to maintaining high scientific and data quality standards Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams Strong communication skills for interacting with internal teams, collaborators, and stakeholders Highly organised with the ability to function effectively in a fast-paced research environment Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h