Scientist II / Senior Scientist, ADME

Job description

**Company Overview** Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets. **Position Overview** The Scientist II / Senior Scientist, ADME will contribute to the design and execution of nonclinical pharmacokinetics/PKPD/ADME strategies to support oncology drug candidates from discovery through development. This role will partner closely with cross-functional teams to deliver high-quality data that informs decision-making and regulatory submissions. Reporting to the Executive Director, Head of ADME, the Scientist II will work on multiple modalities, with a strong emphasis on ADC programs. **Responsibilities** - Perform modeling and simulation, analyze PKPD and PK/TK data, and provide clear interpretation to inform program decisions. - Design and execute stage-appropriate PKPD and ADME studies to support candidate selection, clinical development, and regulatory submissions. - Collaborate with cross-functional teams to ensure integration of ADME considerations into program strategy and timelines. - Participate in Translational Sciences and Development team activities, contributing scientific expertise in ADME. - Represent the ADME function at internal and external meetings, in collaboration with senior scientists, communicating timelines, data, and implications effectively. - Maintain awareness of evolving best practices and regulatory expectations in ADME sciences. **Qualifications** - PhD in a relevant discipline with 0–3 years of industry experience in ADC PKPD and ADME, or MS with 5+ years relevant industry experience. - Experience with ADCs required; additional experience with small molecules, monoclonal antibodies, or other modalities preferred. - Hands-on expertise in PKPD modeling, PK/TK analysis, and study design. - Knowledge of both non-regulated and regulated bioanalysis. **Knowledge and Skills** - Strong problem-solving skills with the ability to manage multiple projects in a fast-paced environment. - Excellent communication skills, with the ability to present complex scientific data clearly to diverse audiences. - Collaborative approach with the ability to work across disciplines to achieve program goals. Level and compensation will be commensurate with relevant experience. Washington State Pay Range $149,930—$203,961 USD **E/E/O** Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. **E-Verify** Immunome, Inc. is a participant in E-Verify. Please review the following notices: [E-Verify Participation Poster](https://immunome.box.com/s/bopxukipfidxjscs4bjxt75f90bvpppk) | [Right to Work Poster (English)](https://immunome.box.com/s/r51g9subw1wqni9xkutbl6up635sjr8e) | [Right to Work Poster (Spanish)](https://immunome.box.com/s/r3ekbimwh988my9vzl76tnlbg60zvh9u).