Scientist, RNA Biochemistry

Job description

About Us Cloverleaf Bio is an early-stage therapeutics company that is developing a new class of engineered tRNA therapeutics. Our tRNAs target an underappreciated vulnerability of cancer: addiction to high levels of tRNA modifying enzymes. Cloverleaf’s approach to drugging tRNA modifying enzymes uses engineered “trojan horse” tRNAs to modulate translation in cancerous cells. The programmability, potency, and specificity of our tRNAs gives us the potential to dramatically improve cancer treatment. The Job We are seeking an experienced RNA Biochemist to join our team. In this position, you will work in close conjunction with our founding team in the creation and development of a completely novel family of RNA therapeutics. Your responsibilities will range from designing and performing both low and high-throughput RNA screening assays, generation of RNA sequencing libraries, performing mechanistic studies in cells on lead candidate RNAs, and diving into new disease areas beyond oncology. About You Excited by the science. We are excited by how science can improve the world and are looking for people who are too. Flexible. We wear many different hats and are looking for people who are willing to do whatever it takes to pitch in and get the job done. Resilient. Working in an early-stage startup can be hard. Science is hard. We are looking for people who have a demonstrated track record of sticking with complex problems for the long haul. Cooperative. As a small team, communication and collaboration are key. We are looking for people who thrive working both independently and collaboratively. Qualifications: PhD in Biochemistry, Molecular Biology, Genetics or related fields. Strong problem solving skills. Demonstrated ability to independently drive research projects to completion in academic or industrial settings. Experience with standard molecular biology techniques, including but not limited to, RNA/DNA extraction, PCR, RT-PCR, qPCR, western blotting, etc. Skilled in mammalian cell culture, passaging/seeding cells, etc. Nice to haves: Competency generating libraries for RNA sequencing (such as mRNA-seq, CLIP-seq, etc.). Comfortable at analyzing NGS data analysis using conventional bioinformatics tools. Research experience in tRNA, RNA biology and/or RNA modifications field. Experience with design/development RNA therapeutics and lipid nanoparticles. Experience with mouse models of oncology. Benefits Competitive salary commensurate with experience and strong equity incentives. Medical, dental, and vision coverage. Brand new lab space in BioLabs New Haven in downtown New Haven, close to the Yale Shuttle, I-95/91 and Metro North. We will provide a stimulating, collegial, and fast-paced environment. If you are interested in joining our team, then we are excited to hear from you! Please submit resumes at