(Scientist) Sr. Scientist, Cardiovascular and Metabolic Disease

Company Summary

ProFound™ Therapeutics is a biotechnology company discovering novel proteins across the expanded human proteome to unlock first-in-class medicines and transformative drug targets. The company’s proprietary ProFoundry™ Platform integrates state-of-the-art protein detection, validation, and computational technologies to systematically identify and characterize previously inaccessible proteins and validate their therapeutic potential. This approach has generated a rapidly expanding portfolio of novel targets and programs advancing toward the clinic, along with strategic collaborations with leading pharmaceutical partners. For more information, please visit www.profoundtx.com.

Position Summary

We are seeking an exceptional Scientist or Senior Scientist to lead and support discovery efforts in projects in Cardiovascular and Metabolic Disease. This role will contribute to shaping our pipeline, bringing scientific leadership and creativity to target validation, drug discovery translational biology. The ideal candidate brings a strong foundation in cardiovascular or metabolic disease biology, a passion for novel biology, and experience designing and executing mechanistic and pharmacology studies that bridge in vitro and in vivo models

This is a high-impact, cross-functional role with the opportunity to work closely with platform scientists, computational biologists, and drug discovery teams to identify and advance novel targets into drug development.

Key Responsibilities

• Drive discovery research in cardiovascular and/or metabolic disease areas by designing, executing, and interpreting mechanistic studies using state-of-the-art models and technologies
• Lead target validation efforts informed by proteomic and computational insights; develop hypotheses and prioritize targets with high translational potential
• Collaborate with computational biology and proteomics teams to interpret large-scale datasets (e.g., proteomic, transcriptomic, genetic) and generate novel biological insights
• Design and oversee in vitro and in vivo models of disease to support target biology, candidate selection, biomarker development, and proof-of-concept studies
• Contribute to building and refining the company’s therapeutic strategy in CVD/metabolic disease
• Communicate findings clearly and effectively in cross-functional team meetings, external collaborations, and presentations to leadership
• Support or lead external academic and industry collaborations

Qualifications

Required

• Ph.D. in physiology, pharmacology, cell biology, or a related field; postdoctoral training or industry experience strongly preferred
• 2+ years (Scientist) or 5+ years (Senior Scientist) of relevant postdoctoral or industry experience
• Experience working in biotech or pharma; experience with cellular assays and in vitro pharmacology assays. Hands-on expertise in cellular/molecular biology techniques (e.g., CRISPR, ELISA, qPCR, Western blotting, RNAseq) and assay development
• Strong track record of scientific contributions (publications, patents, presentations)
• Excellent communication, collaboration, and organizational skills in a fast-paced, team-oriented environment

Preferred

• Deep understanding of disease mechanisms and translational models in one or more areas: obesity, type 2 diabetes, atherosclerosis, heart failure, MASH, lipid metabolism or vascular disease.
• Ability to integrate multi-omic or genetic data into experimental design
• Familiarity with target identification and validation processes
• Experience with human tissue samples, iPSC-derived systems, or organoid models is a plus

Values and Behaviors

We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort working in and contributing to a dynamic and cross-functional team environment. The level of the role will be commensurate with the education and years of experience of the identified candidate.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

ABOUT FLAGSHIP PIONEERING:

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.