Scientist to Senior Scientist, Bioanalysis

Job description

SUMMARY Brii Biosciences is seeking a highly motivated and experienced bioanalytical expert to join our dynamic R&D team. This role will serve as the BA subject matter expert across Brii’s portfolio, supporting programs from early discovery through clinical development. The successful candidate will have strong analytical skills and sample processing experience in various biological matrices including but not limited to plasma, urine, tissues etc. across all relevant preclinical species. The successful candidate will have practical experience working in CRO or biotech/pharmaceutical industry environment with a proven track record for design, execution, assay development and troubleshooting of in vitro and in vivo bioanalytical studies in the context of drug candidate progression. This role involves working as part of a global multi-disciplinary research and development team to profile, characterize and ensure a detailed understanding of the bioanalytical properties of various program assets. This person will work closely with the pharmacology & toxicology teams to ensure the correct studies and interpretation of data are made. The candidate should have excellent oral and written communication skills. DUTIES AND RESPONSIBILITIES Design, execute, analyze, and interpret early discovery bioanalytical studies involving test articles in various biological matrices from different species to support SAR, lead optimization and candidate selection Participate in the design and execution of DMPK and TK studies for discovery through IND-enabling programs as well as providing subject matter expertise to support and enable IND submissions Design, optimization and execution of analytical method development in house as well as oversight of similar external CRO technical activities Responsible for communication and management of outsourced CROs, as well as bioanalytical method development, qualification or validation, and sample analysis to ensure data accuracy and reliability, timelines, and compliance Collaborate cross-functionally with CMC, preclinical and clinical development teams QUALIFICATIONS A master’s degree in pharmacology, chemistry or a related field with more than 3 years of hands-on experience or a bachelor’s degree in a related field with more than 8 years of experience Proven experience of independent designing, execution and assay development and troubleshooting in bioanalytical studies A good understanding of standard DMPK workflows and strong analytical skills for biological samples. Strong data analysis and problem-solving skills with the ability to drive multiple tasks in parallel Experience supporting candidate selection, exploratory toxicology, or IND-enabling studies is preferred Good teamwork and cross-functional communication skills Prior experience with RNAi therapeutics is a plus; familiarity with delivery systems including drug conjugates, lipid nanoparticles and their impact on biodistribution and exposure is preferred Good English proficiency, with the ability to read scientific literature and communicate effectively in daily work The above is intended to describe the general content of and requirements for the performance of this job. It is not to be construed as an exhaustive statement of duties, responsibilities or physical requirements. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. Brii Biosciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, genetic information, protected veteran status, or any other characteristic protected by law. We value diversity and are committed to creating an inclusive environment for team members from all backgrounds.