Senior Director, Legal and Compliance Operations

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Senior Director, Legal and Compliance Operations, is a key leader responsible for supporting the execution and continuous improvement of Madrigal’s Compliance Program. This role focuses on project management, policy governance and operational excellence across the Legal and Compliance function. The Senior Director partners closely with the Global Compliance Officer, Chief Legal Officer, and cross-functional stakeholders, including Compliance, Legal, Commercial, Medical Affairs, Market Access, and IT—to ensure legal and compliance initiatives are effectively implemented and aligned with business objectives. This role plays a critical part in strengthening a culture of integrity, transparency, and ethical decision-making across the organization. The ideal candidate brings deep expertise in healthcare compliance and legal operations, along with a practical, solutions-oriented approach to implementing scalable processes, enhancing training effectiveness, and advancing compliance program maturity. This role offers the opportunity to play a meaningful part in advancing a high-impact compliance program while partnering across the organization to support business success through strong, practical compliance practices. Position Responsibilities The key responsibilities for this role include: Partner with Compliance and Legal team members to maintain and enhance infrastructure that supports a culture of compliance and shared accountability across the organization. Project management tied to legal and compliance operational excellence with sub-functions - creating metrics /key performance indicators/dashboards, etc. Collaborate cross-functionally to identify policy and guidance needs; develop and refine policies, procedures, and supporting documentation to ensure clarity and usability. Lead the design, implementation, and continuous improvement of risk-based compliance training programs tailored to functional audiences. Support the annual compliance risk assessment process, including data gathering, analysis, and identification of areas for program enhancement. Provide practical compliance guidance to business stakeholders and support the integration of compliance controls into existing business processes. Drive continuous improvement initiatives, including documentation, tracking, and reporting of compliance activities and program effectiveness. Maintain current knowledge of applicable laws, regulations, and industry guidance, including federal and state pricing regulations, privacy laws, OIG and DOJ guidance, the PhRMA Code, and state marketing compliance requirements. Lead and execute high-impact legal and compliance projects and cross-functional initiatives as assigned by the Chief Legal Officer or Global Compliance Officer. Educational Requirements Bachelor’s degree required; advanced degree (JD, MBA, or Master’s) strongly preferred. Experience & Qualifications 12–15+ years of progressive experience in pharmaceutical or biotech compliance, legal, or related functions. Demonstrated success in implementing policy governance frameworks and compliance training programs. Strong leadership capability, organizational awareness, sound judgment, and business acumen, with the ability to make informed decisions in collaboration with stakeholders. Excellent interpersonal, written, and presentation skills. Proven ability to operate effectively in a fast-paced, high-growth environment while maintaining a focus on quality, ethics, and collaboration. Knowledge of laws, regulations, and industry guidance relevant to the pharmaceutical industry. Strong collaboration skills and ability to work effectively across cross-functional teams. Strong problem-solving and risk assessment capabilities. Ability to prioritize and manage multiple complex and confidential initiatives simultaneously. Key Competencies Execution and Operational Excellence Cross-Functional Collaboration Risk-Based Decision Making Continuous Improvement Mindset Communication and Influence Integrity and Ethical Leadership Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $254,000 - $311,000 per year. We comply with all applicable minimum wage laws. All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact . Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to .