Senior Manager, AI Portfolio & Prioritization Lead

Role Summary The AI Portfolio & Prioritization Lead reports directly to the AI Strategy & Realization Lead within PGS Data, Analytics & AI Transformation. This role owns PMO management across the AI Strategy & Realization team, providing the portfolio discipline that ensures the right work is being prioritized, resourced, and delivered against strategic value. The role owns intake and prioritization of projects and programs across all pillars of the AI Strategy & Realization team, sequencing work based on strategic alignment, value, and capacity. It manages financial tracking for the full portfolio, and partners with the PGS Data, Analytics & AI Transformation portfolio team and the Spark team to ensure PGS is applying consistent intake, value realization, and inventory standards across all teams. The leader captures, tracks, and holds pillar teams accountable for value realization, and partners with the PGS and Digital Responsible AI team to ensure the portfolio adheres to compliance and governance standards, including AIRIF, DPAL, and ITRM. By bringing rigor and visibility to portfolio sequencing, this role enables the AI Strategy & Realization team to focus effort on the initiatives that matter most and demonstrate the value they deliver. Role Responsibilities Own PMO management and portfolio sequencing across the AI Strategy & Realization team, reporting directly into the AI Strategy & Realization Lead on portfolio health and priorities. Lead prioritization and intake of projects and programs based on strategic initiatives and value, establishing a consistent, transparent process for evaluating and sequencing new and in-flight work. Partner with the PGS Data, Analytics & AI Transformation portfolio team and the Spark team to ensure the AI Strategy & Realization team is utilizing the same intake, value realization, and inventory standards used across PGS. Manage financial tracking for the portfolio of projects across all pillars of the AI Strategy & Realization team, maintaining an accurate, current view of investment and spend. Capture, track, and hold pillar teams accountable for value realization, ensuring benefits are defined, measured, and reported consistently across the portfolio. Partner with the PGS and Digital Responsible AI team to ensure the portfolio adheres to compliance and governance standards, including AIRIF, DPAL, and ITRM. Maintain a single, current inventory of AI Strategy & Realization initiatives, providing leadership-ready reporting on status, risk, and resourcing across pillars. Identify capacity constraints and competing priorities across the portfolio, and escalate trade-off decisions to the AI Strategy & Realization Lead and pillar leaders as needed Basic Qualifications Applicant must have a bachelor’s degree in Business, Information Systems, Computer Science, or a related field with at least 6 or more years of experience; OR a master’s degree with at least 5 years of experience, OR a PhD with at least 1 year of experience. Demonstrated experience running a PMO, portfolio management function, or project intake process within a large, matrixed organization. Working knowledge of prioritization and value realization frameworks, with the ability to translate strategic priorities into a sequenced, resourced portfolio. Experience with financial tracking and reporting for a multi-project or multi-program portfolio. Ability to partner effectively with adjacent portfolio, governance, and compliance teams to align standards and ways of working across organizations. Familiarity with AI/analytics governance and compliance concepts, with the ability to work with frameworks such as AIRIF, DPAL, and ITRM. Excellent organizational, analytical, and communication skills, with the ability to hold stakeholders accountable without direct authority. Preferred Qualifications Strong Pfizer colleague network, particularly across PGS, Digital, and Data, Analytics & AI Transformation, with a track record of forming partnerships to accomplish common goals in highly complex areas. Experience with Pfizer's portfolio, intake, and value realization standards, including familiarity with the Spark team's ways of working. Familiarity with Pfizer's responsible AI and technology risk/compliance frameworks (e.g., AIRIF, DPAL, ITRM). Experience in pharmaceutical manufacturing or supply chain operations. Proven program or portfolio management capability, with experience successfully executing initiatives across large, globally distributed teams. Non-Standard Work Schedule, Travel or Environment Requirements Ability to travel domestically and internationally up to 10% of the year. Willingness to work off-hours to accommodate global time zones and support pillar teams and stakeholders across sites. Willingness to work extended or non-standard hours during peak periods, such as portfolio planning cycles, financial reporting deadlines, and value realization reviews. Other Information Last Date to Apply: October 28, 2026 The annual base salary for this position ranges from $124,400.00 to $207,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply, your Talent Advisor will share the local pay information with you during the first interview. Relocation assistance may be available based on business needs and/or eligibility. Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. 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