Senior Manager/Associate Director, Quality & Supply Chain Systems

Job description

***Who We Are:*** Xenon Pharmaceuticals ([NASDAQ:XENE](https://www.nasdaq.com/market-activity/stocks/xene)) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. ***What We Do:*** We are advancing an [exciting product pipeline](https://xenon-pharma.com/pipeline) to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. ***About the Role:*** We are seeking a **Senior Manager/Associate Director, Quality & Supply Chain Systems** to join our team. The Senior Manager/Associate Director, Quality & Supply Chain Systems will support the implementation and management of the Quality and Supply Chain IT systems. This individual will partner with leaders across Quality and Supply Chain, and other functions as needed to drive adoption, operations, and ongoing enhancements to the IT systems. This position reports to the Director, Development Information Systems and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week. **RESPONSIBILITIES:** - Partner with functional stakeholders and vendors to build new solutions supporting the Quality and Supply Chain functions, including integrations between systems and between Xenon and key service providers. - Author, review, and approve applicable SDLC deliverables, and coordinate assurance and other testing activities. - Develop, review, and approve procedures defining System Administration activities. - Collaborate with Xenon’s Architecture Review Board to ensure the system design is consistent with company standards for security, infrastructure, and data architecture. - Own the day-to-day operations and configurations of Supply Chain Systems (iStability, Oracle Fusion ERP, etc.). - Support the day-to-day operations and configuration of the Veeva Development suite (RIM, Quality, etc.). - Support the day-to-day operations and configuration of other Development IT systems (SAS, Egnyte, etc.). - Maintain hands on involvement in system administration and configuration, including workflows, metadata, security, reference data, and system settings. - Perform user administration and manage licensing across Quality and Supply Chain IT systems. - Support the design, development, and documentation of effective data flows and integrations among systems to enable efficient processes and workflows (including automation) and effective reporting and analytics. - Support user onboarding, system training, and operational adoption from a system and process perspective. - Collaborate with key stakeholders to develop and maintain roadmaps, continuous improvement initiatives, and system standardization efforts. - Manage vendor/MSP relationships related to IT systems. - Provide technical guidance and support on change control activities. - Ensure ongoing compliance with Xenon procedures including SaaS Release Management, Change Management, Problem Management, etc. - Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any. - Other duties as assigned. **QUALIFICATIONS:** - Bachelor’s degree in Information Systems, Computer Science, Business Administration or related field. - Minimum of 5 years of relevant experience, preferably in the Life Sciences industry. Experience supporting pre commercial or early commercial biotech organizations preferred. - Proven experience with the Veeva suite of products, Supply Chain planning and execution systems (including ERP), and other key Development IT systems (Veeva certification a plus). - Strong understanding of the Quality and Supply Chain business processes. - Knowledge of user management administration. - Experience managing vendors/MSPs and collaborating with business stakeholders to prioritize support or enhancement requests. - Experience with system integrations (APIs, data flows, connectors). - Excellent communication and coordination skills across business and technical teams. - Ability to manage multiple priorities in a fast-paced environment. - Strong problem-solving skills and attention to detail. Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions. Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.