Senior Manager, Internal Controls

Join us as we transform immunology and deliver medicines that help autoimmune patients get their lives back. argenx is preparing for multi-dimensional expansion to reach more patients through a rich pipeline of differentiated assets, led by VYVGART, our first-in-class neonatal Fc receptor blocker approved for the treatment of gMG, and with the potential to treat patients across dozens of severe autoimmune diseases. We are building a new kind of biotech company, one that maintains its roots as a science-based start-up and pushes our commitment to innovate across all corners of our business. We strive to inspire and grow our company, our partnerships, our science, and our people, because when we do, we deliver more for patients. PURPOSE OF THE FUNCTION Lead the execution and continuous evolution of argenx's SOX framework across Financial Reporting & Consolidation and Tax cycles, ensuring a risk-based control environment that supports reliable financial reporting and scalable growth. Partner with Finance and the business to embed effective controls into strategic initiatives and digital solutions, while coordinating cycle-specific Internal Audit and External Audit activities and promoting a strong culture of risk awareness and control ownership. ROLES AND RESPONSIBILITIES SOX Compliance Lead the end-to-end SOX program for and drive the scalable evolution of the Financial Reporting & Consolidation and Tax cycles, ensuring ICFR effectiveness in accordance with Section 404 of the Sarbanes-Oxley Act of 2002 and related SEC rules and regulations. Drive SOX scoping and risk assessment activities, partnering with Finance and business stakeholders to design scalable internal controls for complex transactions, strategic initiatives and evolving business processes. Evaluate control deficiencies, perform severity assessments, and drive timely remediation in partnership with control owners. Internal Control Transformation Drive opportunities for simplification, standardization and automation that strengthen the effectiveness, scalability, and future readiness of the control framework through innovation, aligned with argenx’s Vision 2030 ambitions. Act as a trusted advisor to Finance and the broader organization on financial reporting risks, embedding effective internal controls into strategic initiatives and digital solutions. Audit Management Lead the coordination of SOX management testing with Internal Audit and act as the primary point of contact for External Audit, ensuring on-time execution of the audit plans, timely fulfillment of audit requests, and effective cross-functional collaboration. Control Awareness Build strong partnerships across Finance and the business to promote a culture of risk awareness, control ownership and accountability, supported by practical guidance and training. What Success Looks Like A scalable, future-ready control framework that keeps pace with argenx's growth and is aligned with argenx’s Vision 2030 ambitions. Reliable financial reporting supported by an effective and sustainable SOX environment. Control deficiencies identified early, assessed consistently, and remediated in a timely manner. Controls embedded into evolving business processes, strategic initiatives, and digital solutions. Strong stakeholder engagement, resulting in clear ownership and accountability for risks and controls. Efficient audit execution with high-quality outcomes and constructive auditor relationships. SKILLS AND COMPETENCIES Essential Experience University degree in Finance, Business Administration, Accounting, or a related field (required). 6+ years of progressive experience in internal controls, external audit and/or internal audit. Proven experience in designing, implementing, and monitoring internal control frameworks within a US-listed environment, partnering with local, regional and global teams to drive control effectiveness and SOX compliance. Demonstrated ability to coordinate SOX management testing with Internal Audit and effectively manage External Audit requirements and stakeholder engagement. Experience in biotechnology, pharmaceuticals or life sciences is a strong asset. Proficiency in English; additional languages are an advantage. Technical Strengths Ability to understand end-to-end business processes and associated risks and translate them into scalable and sustainable control solutions. Strong analytical and problem-solving capabilities, using data-driven insights to navigate complex business and control challenges while applying sound risk judgement. Experience evaluating control deficiencies and driving sustainable remediation. Ability to challenge the status quo and support transformative improvements across business processes through automation, simplification and scalable control design. Strong understanding of the Sarbanes-Oxley Act (SOX), COSO principles, PCAOB auditing standards, and other regulatory compliance frameworks. Knowledge of IFRS and its application to financial reporting risks and controls is considered a strong plus. Leadership & Culture Trusted partner capable of leading cross-functional initiatives and influence stakeholders across multiple teams to achieve effective governance and controls. Demonstrate ownership, integrity and sound judgment. Structured communicator who can explain complex topics in a clear and practical manner. Ability to work collaboratively and effectively together within cross-functional teams and networks Demonstrated communication skills, within a multi-cultural and multi-lingual global environment Is agile and demonstrates adaptability, comfort with ambiguity, trust-building, and resilience Derives energy from operating in a dynamic, complex, fast-moving, and frequently changing business environment Demonstrable experience with project management, proactive planning, priority setting, and securing alignment Drives toward outcomes Ambitious, inquisitive naturally, a quick study, with demonstrated eagerness to continuously learn, self-improve and develop. This includes being comfortable giving and receiving feedback in a diverse environment. Passionate and prepared to lead and contribute to our culture, which is driven by our corporate values of co-creation, innovation, empowerment, excellence , and humility. OTHER Periodic international travel required to partner with regional Finance teams, oversee control activities and coordinate internal and external audit requirements. #LI-Hybrid ‎ The annual base salary hiring range for this position is €89,600.00 - €123,200.00 EUR This job is eligible to participate in our short-term and long-term incentives program. The hiring range displayed above is the range of possible base pay compensation that argenx believes in good faith it will pay for this role at the time of this posting. The hiring range is based on the job grade for this position. Individual compensation paid within this range depends on a variety of factors, including, but not limited to, internal equity, prior education and experience, job-related knowledge and demonstrated skills. argenx may pay more or less than the posted range and this range may be modified in the future. At argenx, all applicants are welcomed in an inclusive environment. They will receive equal consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other applicable legally protected characteristics. argenx is proud to be an equal opportunity employer. Before you submit your application, CV or any other personal details to us, please review our argenx Privacy Notice for Job Applicants to learn more about how argenx B.V. and its affiliates (“argenx”) will handle and protect your personal data. If you have any questions or you wish to exercise your privacy rights, please contact our Global Privacy Office by email at .