Senior/Principal Scientist, Synthetic Biology

Job description

### **About the company** Fieldstone Bio is an early-stage synthetic biology company focused on environmental monitoring. [Our technology, which originated at MIT,](https://techcrunch.com/2025/05/15/fieldstone-bio-is-building-microbes-that-can-sense-everything-from-tnt-to-arsenic/) combines microbiology, synthetic biology, artificial intelligence, and advanced imagery to solve key challenges in mining, pollution surveillance, and national security. ### **Position summary** Fieldstone Bio is looking for a highly motivated Senior Scientist or Principal Scientist to join our growing Synthetic Biology team, where they will work to design, build, and test microbial biosensors for function in lab-, soil-, water-, and rock-based environments. Target molecules for these biosensors will include metals (for mining applications) and small molecules relevant to Fieldstone’s ongoing and future programs. This role will drive development of biosensors for small molecules with no known regulators, requiring expertise in transcriptomics-based approaches and/or experience in protein engineering and directed evolution. A successful candidate will independently contribute to sensor design, construction, and testing, leveraging synthetic biology expertise to identify the genetic parts and microbial chassis most suited for the program. This is a lab-based role that will work collaboratively with the company’s Microbiology team and AI Data team. This role provides a unique opportunity to impact the development of research and development strategies at an early-stage biotechnology company. This role is on-site and located in Woburn, MA. #### **Key Responsibilities:** - Design, build, and test microbial biosensors for target molecules of interest - Develop biosensors for target molecules with no known regulators using RNA-sequencing and genome-mining approaches - Improve existing biosensors via protein engineering, directed evolution, and screening-based approaches - Collaborate with Microbiology team to identify synthetic biology solutions to support successful biosensor deployment in the target environment - Interface with leadership team to refine select program’s technical strategies - Ensure timely delivery of goals for set milestones - Clearly present scientific findings in cross-functional project team meetings - Document processes, SOPs, and results in an Electronic Lab Notebook (ELN) system #### **Qualifications:** - Ph.D. (or equivalent) in Bioengineering, Chemical Engineering, Microbiology (or related field) and a minimum of 2+ years of industry experience - Demonstrated success in microbial engineering with a proven track record of sensor development, preferably with experience engineering microbes for function outside of a lab environment - Expertise in DNA design and assembly of complex plasmids - Depth of knowledge of current technologies used for identifying and screening novel microbial biosensors, including transcriptomics- and bioinformatics-based approaches - Experience with engineering non-model microbes and engineering microbes for function in complex non-lab environments is a plus - Strong analytical and problem-solving skills and outside-of-the-box thinking - Ability to work independently and manage multiple tasks simultaneously - Excellent verbal and written communication - Versatile and flexible scientist who thrives in a fast-paced and collaborative lab environment *Fieldstone Bio is committed to building a diverse and inclusive environment. All applicants will be considered without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status or disability.*