Senior Scientist, Structural Biology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at . As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Biological Research Job Category: Scientific/Technology All Job Posting Locations: Spring House, Pennsylvania, United States of America Job Description: We are searching for the best talent for our Senior Scientist, Structural Biology position to be located in Spring House, PA. About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at Purpose: Join J&J’s Structural Biology team as a Senior Scientist to drive high‑impact structural studies that accelerate therapeutic discovery. You will lead end‑to‑end structural biology activities from sample preparation, structure determination, to cross‑functional interpretation for the discovery of therapeutic antibodies as well as other modalities. This role is designed for a PhD scientist who brings strong research training, scientific curiosity, and enthusiasm for learning in a collaborative drug-discovery environment. You will be responsible for: Purify, assemble, and characterize antibodies, antigens, Fab–antigen complexes, and related protein assemblies for structural studies. Prepare and screen cryo-EM grids, evaluate sample quality, and optimize biochemical and vitrification conditions with guidance from experienced colleagues. Process cryo-EM data and contribute to particle picking, classification, three-dimensional reconstruction, model building, refinement, and validation. Analyze antibody–antigen interfaces, epitopes, conformational states, and structure–function relationships to inform antibody discovery and optimization. Use complementary structural and biophysical approaches, including negative-stain EM, crystallography, or solution-based characterization, where appropriate. Maintain clear experimental records, assess data quality, troubleshoot workflows, and communicate results and recommendations to multidisciplinary teams. Collaborate with biologics discovery, protein sciences, biophysics, in silico discovery, and project teams to advance therapeutic programs. Contribute to scientific presentations, reports, publications, and continuous improvement of structural biology workflows. Qualifications/ Requirements: PhD in Structural Biology, Biochemistry, Biophysics, or a related discipline with 2 years relevant postdoctoral or industry experience; or MS with 4 years of industry experience is required. Hands-on research experience in antibody–antigen structural biology, protein complexes, or a closely related area is required. Experience with single-particle cryo-EM, including sample preparation, grid screening or optimization, data processing, and structure determination, is required. Experience with protein expression, purification, complex assembly, and biochemical or biophysical characterization is required. Working knowledge of cryo-EM software and structural analysis tools is required. Ability to interpret structural data, recognize data-quality limitations, troubleshoot experiments, and communicate findings clearly is required. Strong collaboration, organization, scientific writing, and problem-solving skills are required. Experience studying antibodies, antigens, epitopes, or immune protein complexes is preferred. Experience with negative-stain EM, X-ray crystallography, Cryo-ET, or complementary biophysical methods is preferred. Familiarity with antibody discovery, structure-guided design, or biologics drug discovery is preferred. Track record of published structures and demonstrated impact on drug discovery projects is preferred. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource. If you are under 18 years of age you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent’s consent for the background check. #LI-Hybrid Required Skills: Preferred Skills: Accelerating, Analytical Reasoning, Clinical Data Management, Critical Thinking, Data Analysis, Data Reporting, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Issue Escalation, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Technologically Savvy