Sr/Exec Director GI Medical Strategy

erasca

San Diego, CA or remote · San Diego · United States

Posted Aug 10, 2026

Other
Remote
Development

Job description

Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.

Position Summary: 

Reporting to the VP of Medical Affairs, the Senior or Executive Director, GI Medical Strategy will drive the overarching medical strategy and execution for GI cancers with a focus toward pancreas cancer. This person will work closely with cross-functional teams in the development, management, and execution of the clinical development plan, evidence generation strategy, scientific narrative, and KOL engagement strategy. The Senior or Executive Director, GI Medical Strategy will serve as a GI cancers subject matter expert and key thought partner, both internally and externally, and will have individual responsibility for growing and developing the medical affairs function within GI cancers at the company.

Note that this position can be hybrid in San Diego, CA or South San Francisco, CA or fully remote anywhere in the United States.

Essential Duties and Responsibilities:

Strategic and tactical lead for GI cancers in Medical Affairs. Coordinates across all Medical Affairs, R&D, and other functions by developing and maintaining strategic plans and budgets.
Partners across internal stakeholders in the development of the GI cancers overall medical strategy, clinical development plan, evidence generation strategy, scientific narrative, and KOL engagement strategy.
Collaborates and drives GI cancers tactical planning. Manages execution of Medical Affairs activities including publication development, insight generation initiatives, medical communications, evidence generation, training, and early access.
Serves as a subject matter expert in gastrointestinal oncology with an emphasis on precision therapeutics in pancreas cancer. Assimilates emerging information into existing disease state and competitive context.
Develops and manages strategic relationships with GI oncology thought leaders.
Facilitates relationships with external societies, advocacy groups, and alliance partner engagements.
Leads Medical Affairs GI oncology research studies including phase 4 company sponsored research, registries, investigator sponsored research, collaborative trials, meta-analyses, and retrospective studies. Provides scientific expertise on study design, rationale, and alignment to strategy.
Perform all duties in keeping with the Company’s core values, policies, and all applicable regulations.

Required Education and Experience:

Advanced degree (MD, PhD, PharmD) in a medical or science specialty preferred, significant experience in the medical field may be considered in lieu of an advanced degree
8+ years of related experience at a pharmaceutical company in medical affairs or clinical development role
Significant understanding and experience in GI cancers required; including evolving disease, treatment, and thought leader landscapes
Strong scientific acumen required to communicate with key internal and external stakeholders.
Firm understanding of the strategy and processes that are involved in both the non-clinical and clinical aspects of drug development
Strong and timely communication skills, both oral and written, and capability to build trust and respect of partners
Leads with influence, vision, and positive intent; culture builder
Agility and flexibility in working across diverse therapeutic areas in a fast-paced growth stage biotech company
Proven track record of timely decision making, prioritization, and a solution-oriented mindset in successfully addressing objectives
Demonstrated ability to achieve high-performance goals and meet deadlines in a fast-paced environment; a collaborative team player with a can-do attitude and the ability to identify and implement creative solutions to complex problems.
Experience managing budgets and vendor partnerships
Demonstrated understanding of legal and compliance environment of pharmaceutical industry.
Strong learning orientation, curiosity, and commitment to science and patients
20-35% domestic and international travel required to attend key internal and external professional meetings

The anticipated salary range for this position is $270,000 to $325,000 for a non-MD. The final salary offered to a successful candidate will be dependent on several factors that may include but are not limited to the type and length of experience within the job, type and length of experience within the industry, education, etcetera. In addition to base salary, the hired applicant will be eligible to receive an annual bonus and an equity grant at hire and annually in the form of the option to purchase stock in the future for a specified price.

Along with our casual, collaborative, and fun work and the chance to make your mark in our mission to erase cancer, Erasca offers a comprehensive and competitive benefits package that includes: Paid Time Off, Holiday, and Sick Leave, Medical, Dental and Vision Plans, Short- and Long-Term Disability, Basic and Voluntary Life/AD&D Coverage, Flexible Spending Accounts (FSA, HSA, and Commute), Critical Illness and Accident Coverage, Pet Insurance, Employee Assistance Program, 401(k) Plan with Erasca contribution, and the opportunity to participate in an Employee Stock Purchase Program.

Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race, religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation.