Sr Program Manager, Compliance & Salesforce Governance
twistbioscience
USA - South San Francisco, CA
Posted Aug 26, 2026
- Other
- General & Administration
Job description
## Sr Program Manager, Compliance & Salesforce Governance ## **(Hybrid in South San Francisco)** ### Summary Twist Bioscience is seeking a Senior Program Manager to lead IT Governance, Risk & Compliance (GRC), SOX control framework design, and technology governance across the enterprise Salesforce ecosystem. This **senior individual-contributor role** will **own** the **design, implementation, assessment, and continuous improvement of the IT SOX control framework**, ensuring technology risks impacting financial reporting are effectively identified, governed, and mitigated. The role will serve as a strategic **GRC partne**r to **Internal Audit, Internal Controls, Finance, Information Security, Technology**, business process owners, and external auditors like E&Y. ### Core Responsibilities - Own the **design, implementation, and continuous improvement** of the Salesforce IT SOX/GRC control framework. - Translate SOX and technology risks into **effective ITGCs, application controls, policies, and governance standards.** - Embed controls into **solution design, implementations, integrations, and technology changes.** - Lead **risk and control assessments, testing, deficiency remediation, and continuous monitoring.** - Govern **Segregation of Duties (SoD), privileged access, and access reviews.** - Partner with Technology, Finance, Information Security, Internal Controls, and business teams to **strengthen the control environment.** - Lead **SOX audit coordination,** including walkthroughs, evidence, testing, and remediation with Internal Audit and external auditors. - Establish **end-to-end technology governance** across Salesforce and financially relevant integrations, including release governance and control automation. - The role will **coordinate and govern releases but will not develop, independently approve, and deploy the same production change**, preserving appropriate segregation of duties. ### Key Qualifications - **5+ years of experience** in Program Management - Proven experience **designing, implementing, and improving IT control frameworks** within a publicly traded company. - Experience translating business and technology risks into **effective, sustainable controls, policies, and governance standards.** - Experience leading **control assessments, walkthroughs, testing, deficiency evaluation, and remediation** with Internal Audit and external auditors. - Strong understanding of **access, Segregation of Duties (SoD), privileged access, change management, and technology governance controls.** - Experience designing controls across **enterprise applications, integrations, and financially significant systems.** - Strong ability to **influence cross-functional stakeholders and drive governance initiatives** without direct management authority. ### Preferred Qualifications - Experience leading **enterprise GRC or IT SOX control framework** **transformation** and continuous improvement initiatives. - Experience with **Salesforce and/or other enterprise CRM and ERP platforms.** - Experience with **GRC platforms, continuous controls monitoring, and control automation**. - **Salesforce Sales Cloud, Service Cloud, and Data Cloud**. ### **Success in This Role** Success will be measured by establishing a **scalable, sustainable, and risk-based IT GRC and SOX control framework** that: - Withstands **internal and external audit scrutiny** and maintains strong audit readiness. - Identifies and addresses **SOX and financial-reporting risks early,** particularly through technology and solution design. - Maintains effective **control design, ownership, Segregation of Duties, and privileged-access governance.** - Provides clear, consistent **control documentation, evidence, monitoring, and accountability.** - Drives **timely and sustainable remediation** of control gaps and deficiencies. - Enables efficient, consistent governance across **Salesforce, integrations, and downstream financially relevant systems** while supporting business growth and technology innovation. ## About Twist Bioscience Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA. At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers. Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law. The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations. San Francisco Bay Area Pay Range $120,000—$150,000 USD