(StealthCo) Scientist: Biology and Cell Pharmacology

Job description

**About the role:** We are seeking a highly motivated and intellectually agile Scientist to join our stealth-mode biotech company and contribute to programs focused on hematopoietic cell biology. This laboratory-based role will be responsible for designing, executing, and interpreting in vitro experiments that generate actionable insights and support scientific decision-making. The successful candidate will be mechanistically minded, able to connect experimental observations to underlying biology, build novel reproducible assays, and deliver results in a fast-paced environment. The position is a rare opportunity to play a pivotal role in the successful development of new drugs for patients within an early-stage therapeutics company backed by highly regarded investors. **Key Responsibilities:** - Lead efforts to develop a novel therapeutic for the treatment of a hematologic disease with unmet medical need - Develop, optimize, and perform cell-based assays to evaluate the impact of compounds on: - Erythroid differentiation (e.g., flow cytometry markers,morphology) - Cell health (e.g., viability) - Protein-level readouts (e.g., flow cytometry, ELISA, high content imaging, Western blot) - RNA-level outcomes (e.g., qPCR) - Culture and differentiate multiple cell lines using established and custom protocols. - Collaborate with scientists, mentor and train associates in a small biotech startup environment. - Translate and develop selected assays to support *in vivo* pharmacology studies. - Maintain detailed laboratory records, perform data analysis, and present findings in team meetings. - Ensure compliance with all lab safety, quality, and recordkeeping standards. - Oversee research activities with external research organizations (CROs) as needed **Qualifications:** - PhD in Cell Biology, Molecular Biology, or a related field with 0-2 years of industry experience preferred - BS or MS in Cell Biology, Molecular Biology, or a related field with 5+ years of relevant industry research experience will be considered - Proven tissue culture experience with human cell lines and primary human cell culture—ideally CD34+ hematopoietic or other stem/progenitor cells. Familiarity with erythroid differentiation assays and hematopoietic biology is a plus. - Molecular biology expertise including DNA and RNA purification and practical expertise with downstream nucleic acid-based (e.g., qPCR, and RNA-seq) and protein-based assays (e.g. flow cytometry, ELISA, and Western blotting) - Demonstrated experience in building novel cell-based assays is a strong plus. - Excellent attention to detail, organizational skills, and ability to work both independently and collaboratively. - Excellent problem-solving skills and a track record of learning new techniques and scientific concepts quickly. - Strong communication skills for cross-functional teamwork and clear documentation. **What we offer:** - Competitive compensation and benefits - A collaborative, small-team environment with growth opportunities - The opportunity to contribute to innovative drug discovery efforts and join an early-stage biotechnology company backed by highly regarded investors **Location:** Cambridge, MA